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Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ

Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas. We investigated the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS). We designed a deep learning system tailored for the tissue architec...

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Detalles Bibliográficos
Autores principales: Sobhani, Faranak, Muralidhar, Sathya, Hamidinekoo, Azam, Hall, Allison H., King, Lorraine M., Marks, Jeffrey R., Maley, Carlo, Horlings, Hugo M., Hwang, E. Shelley, Yuan, Yinyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477879/
https://www.ncbi.nlm.nih.gov/pubmed/36109587
http://dx.doi.org/10.1038/s41523-022-00419-9