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Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study

AIMS/HYPOTHESIS: Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies and Mendelian randomisation (MR) analyses on this...

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Detalles Bibliográficos
Autores principales: Wang, Wenyi, Luo, Jiao, Willems van Dijk, Ko, Hägg, Sara, Grassmann, Felix, `t Hart, Leen M., van Heemst, Diana, Noordam, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477915/
https://www.ncbi.nlm.nih.gov/pubmed/35867128
http://dx.doi.org/10.1007/s00125-022-05759-6