Cargando…

Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study

AIMS/HYPOTHESIS: Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies and Mendelian randomisation (MR) analyses on this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wenyi, Luo, Jiao, Willems van Dijk, Ko, Hägg, Sara, Grassmann, Felix, `t Hart, Leen M., van Heemst, Diana, Noordam, Raymond
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477915/ https://www.ncbi.nlm.nih.gov/pubmed/35867128 http://dx.doi.org/10.1007/s00125-022-05759-6

Ejemplares similares

Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank
por: van Vliet, Nicolien A, et al.
Publicado: (2021)

Diet‐Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People
por: Martens, Leon G., et al.
Publicado: (2021)

Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus
por: Wang, Wenyi, et al.
Publicado: (2022)

The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study
por: Verkouter, Inge, et al.
Publicado: (2020)

Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study
por: Luo, Jiao, et al.
Publicado: (2022)

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses
por: Bos, Maxime M., et al.
Publicado: (2021)

The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective
por: Meulmeester, Fleur L., et al.
Publicado: (2022)

Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation
por: Tobiasz, Joanna, et al.
Publicado: (2023)

The UK BiLEVE and Mendelian randomisation: using multivariable instrumental variables to address “damned if you, damned if you don’t” adjustment problems
por: Woolf, Benjamin, et al.
Publicado: (2023)

Alternatives for using multivariate regression to adjust prospective payment rates
por: Sheingold, Steven H.
Publicado: (1990)

Prevalence and properties of intragenic copy-number variation in Mendelian disease genes
por: Truty, Rebecca, et al.
Publicado: (2018)

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study
por: Wang, Wenyi, et al.
Publicado: (2021)

Obesity, Fat Distribution and Risk of Cancer in Women and Men: A Mendelian Randomisation Study
por: Loh, Nellie Y., et al.
Publicado: (2022)

Predicting survival of cancer patients by chromosomal copy number heterogeneity
por: Van Den Bosch, Tom, et al.
Publicado: (2021)

Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study
por: Toh, Sengwee, et al.
Publicado: (2019)

Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
por: Hernáez, Álvaro, et al.
Publicado: (2022)

Associations between insomnia and pregnancy and perinatal outcomes: Evidence from mendelian randomization and multivariable regression analyses
por: Yang, Qian, et al.
Publicado: (2022)

The Covariance Adjustment Approaches for Combining Incomparable Cox Regressions Caused by Unbalanced Covariates Adjustment: A Multivariate Meta-Analysis Study
por: Dehesh, Tania, et al.
Publicado: (2015)

Agreement between nicotine metabolites in blood and self-reported smoking status: The Netherlands Epidemiology of Obesity study
por: Folpmers, Sofia, et al.
Publicado: (2022)

Mitochondrial DNA copy number is associated with Crohn’s disease: a comprehensive Mendelian randomization analysis
por: Cai, Xianlei, et al.
Publicado: (2023)

The Association between Habitual Sleep Duration and Sleep Quality with Glycemic Traits: Assessment by Cross-Sectional and Mendelian Randomization Analyses
por: Bos, Maxime M., et al.
Publicado: (2019)

Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
por: Hernáez, Álvaro, et al.
Publicado: (2021)

Pleiotropy robust methods for multivariable Mendelian randomization
por: Grant, Andrew J., et al.
Publicado: (2021)

Bi-directional and multivariate mendelian randomization analysis of the relationship between circulating 25-hydroxyvitamin D concentration and obstructive sleep apnea
por: Luo, Xi, et al.
Publicado: (2022)

Robust Regression Analysis of Copy Number Variation Data based on a Univariate Score
por: Satten, Glen A., et al.
Publicado: (2014)

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data
por: Faquih, Tariq, et al.
Publicado: (2020)

Multivariate wind power curve modeling using multivariate adaptive regression splines and regression trees
por: Mushtaq, Khurram, et al.
Publicado: (2023)

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity
por: Bos, Maxime M., et al.
Publicado: (2020)

Networks: On the relation of bi- and multivariate measures
por: Mader, Wolfgang, et al.
Publicado: (2015)

Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank
por: Young, William J., et al.
Publicado: (2021)

Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder
por: Kember, Rachel L, et al.
Publicado: (2015)

The number needed to treat adjusted for explanatory variables in regression and survival analysis: Theory and application
por: Vancak, Valentin, et al.
Publicado: (2022)

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population
por: Martens, Leon G., et al.
Publicado: (2020)

BCRgt: a Bayesian cluster regression-based genotyping algorithm for the samples with copy number alterations
por: Yang, Shengping, et al.
Publicado: (2014)

Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?
por: Meulmeester, Fleur L., et al.
Publicado: (2022)

Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma
por: van Kempen, Pauline M W, et al.
Publicado: (2015)

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles
por: Noordam, Raymond, et al.
Publicado: (2021)

Improper Reporting of Multivariable Logistic Regression
por: Kumar, Rajeev
Publicado: (2014)

Errors in use of multivariable regression analysis
por: Kumar, Rajeev
Publicado: (2015)

Variable selection in multivariate multiple regression
por: Variyath, Asokan Mulayath, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_al2j124bj4scvllu273f948qpg