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Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation

Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis. In humans, loss-of-function mutations in LRP5 cause Osteoporosis-Pseudoglioma syndrome, a low bone mass disorder, while gain-of-function mis...

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Detalles Bibliográficos
Autores principales:	Khrystoforova, Iryna, Shochat-Carvalho, Chen, Harari, Ram, Henke, Katrin, Woronowicz, Katherine, Harris, Matthew P., Karasik, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478031/ https://www.ncbi.nlm.nih.gov/pubmed/36120446 http://dx.doi.org/10.3389/fendo.2022.985304

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