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Macrophage migration inhibitory factor in acute kidneyinjury
Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis, which lacks early biomarkers and targeted therapy. Recently, macrophage migration inhibitory factor (MIF) family protein have received increasing attention owing to its pleiotropic protein molecule ch...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478040/ https://www.ncbi.nlm.nih.gov/pubmed/36117692 http://dx.doi.org/10.3389/fphys.2022.945827 |
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author | Du, Yiwei Hao, Hao Ma, Heng Liu, Hongbao |
author_facet | Du, Yiwei Hao, Hao Ma, Heng Liu, Hongbao |
author_sort | Du, Yiwei |
collection | PubMed |
description | Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis, which lacks early biomarkers and targeted therapy. Recently, macrophage migration inhibitory factor (MIF) family protein have received increasing attention owing to its pleiotropic protein molecule character in acute kidney injury, where it performed a dual role in the pathological process. macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 are released into the peripheral circulation when Acute kidney injury occurs and interact with various cellular pathways. On the one hand, macrophage migration inhibitory factor exerts a protective effect in anti-oxidation and macrophage migration inhibitory factor-2 promotes cell proliferation and ameliorates renal fibrosis. On the other hand, macrophage migration inhibitory factor aggravates renal injury as an upstream inflammation factor. Herein, we provide an overview on the biological role and possible mechanisms of macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 in the process of Acute kidney injury and the clinical application prospects of macrophage migration inhibitory factor family proteins as a potential therapeutic target. |
format | Online Article Text |
id | pubmed-9478040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94780402022-09-17 Macrophage migration inhibitory factor in acute kidneyinjury Du, Yiwei Hao, Hao Ma, Heng Liu, Hongbao Front Physiol Physiology Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis, which lacks early biomarkers and targeted therapy. Recently, macrophage migration inhibitory factor (MIF) family protein have received increasing attention owing to its pleiotropic protein molecule character in acute kidney injury, where it performed a dual role in the pathological process. macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 are released into the peripheral circulation when Acute kidney injury occurs and interact with various cellular pathways. On the one hand, macrophage migration inhibitory factor exerts a protective effect in anti-oxidation and macrophage migration inhibitory factor-2 promotes cell proliferation and ameliorates renal fibrosis. On the other hand, macrophage migration inhibitory factor aggravates renal injury as an upstream inflammation factor. Herein, we provide an overview on the biological role and possible mechanisms of macrophage migration inhibitory factor and macrophage migration inhibitory factor-2 in the process of Acute kidney injury and the clinical application prospects of macrophage migration inhibitory factor family proteins as a potential therapeutic target. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478040/ /pubmed/36117692 http://dx.doi.org/10.3389/fphys.2022.945827 Text en Copyright © 2022 Du, Hao, Ma and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Du, Yiwei Hao, Hao Ma, Heng Liu, Hongbao Macrophage migration inhibitory factor in acute kidneyinjury |
title | Macrophage migration inhibitory factor in acute kidneyinjury |
title_full | Macrophage migration inhibitory factor in acute kidneyinjury |
title_fullStr | Macrophage migration inhibitory factor in acute kidneyinjury |
title_full_unstemmed | Macrophage migration inhibitory factor in acute kidneyinjury |
title_short | Macrophage migration inhibitory factor in acute kidneyinjury |
title_sort | macrophage migration inhibitory factor in acute kidneyinjury |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478040/ https://www.ncbi.nlm.nih.gov/pubmed/36117692 http://dx.doi.org/10.3389/fphys.2022.945827 |
work_keys_str_mv | AT duyiwei macrophagemigrationinhibitoryfactorinacutekidneyinjury AT haohao macrophagemigrationinhibitoryfactorinacutekidneyinjury AT maheng macrophagemigrationinhibitoryfactorinacutekidneyinjury AT liuhongbao macrophagemigrationinhibitoryfactorinacutekidneyinjury |