Cargando…

Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI

In the last two decades, there has been a growing body of research that identified sex-related differences in attention-deficit hyperactivity disorder (ADHD). Our objective was to quantify whether these sex differences are based on altered functional brain connectivity profiles. In addition, we inve...

Descripción completa

Detalles Bibliográficos
Autores principales: Dupont, Gabriele, van Rooij, Daan, Buitelaar, Jan K., Reif, Andreas, Grimm, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478108/
https://www.ncbi.nlm.nih.gov/pubmed/36117656
http://dx.doi.org/10.3389/fpsyt.2022.962911
_version_ 1784790493890084864
author Dupont, Gabriele
van Rooij, Daan
Buitelaar, Jan K.
Reif, Andreas
Grimm, Oliver
author_facet Dupont, Gabriele
van Rooij, Daan
Buitelaar, Jan K.
Reif, Andreas
Grimm, Oliver
author_sort Dupont, Gabriele
collection PubMed
description In the last two decades, there has been a growing body of research that identified sex-related differences in attention-deficit hyperactivity disorder (ADHD). Our objective was to quantify whether these sex differences are based on altered functional brain connectivity profiles. In addition, we investigated whether the presence of comorbid disorders, including depression, substance use disorder (SUD) and overweight, influenced these sex differences. A seed-based connectivity analysis of the external globus pallidus (GPe), an important inhibitory relay hub of the fronto-thalamo-striatal-loop, was performed. In a first step, we searched for sex-related differences in ADHD patients (N = 137) and separately in healthy controls (HC) (N = 45), after that, we compared an equal group of HC and ADHD patients to compare sex-related differences in ADHD patients and HC. In a second step, we studied whether the neural basis of comorbidity patterns is different between male and female patients. We observed that male ADHD patients demonstrated a decrease in functional connectivity (FC) from the GPe to the left middle temporal gyrus compared to female ADHD patients. Moreover, within the full ADHD group (N = 137), there was a lower FC in male patients from GPe to the right frontal pole/middle frontal gyrus compared to female patients. Male ADHD patients with depression demonstrated decreased FC from the GPe to parts of the occipital cortex compared to female ADHD patients with depression. No such effect was demonstrated for overweight or SUD. The current study reveals different FC profiles in males and females with ADHD, which are centered around altered connectivity with the GPe. An improved understanding of sex-differences in ADHD, and the role of comorbid disorders, therein can result in improved diagnostic and therapeutic opportunities for ADHD patients.
format Online
Article
Text
id pubmed-9478108
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94781082022-09-17 Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI Dupont, Gabriele van Rooij, Daan Buitelaar, Jan K. Reif, Andreas Grimm, Oliver Front Psychiatry Psychiatry In the last two decades, there has been a growing body of research that identified sex-related differences in attention-deficit hyperactivity disorder (ADHD). Our objective was to quantify whether these sex differences are based on altered functional brain connectivity profiles. In addition, we investigated whether the presence of comorbid disorders, including depression, substance use disorder (SUD) and overweight, influenced these sex differences. A seed-based connectivity analysis of the external globus pallidus (GPe), an important inhibitory relay hub of the fronto-thalamo-striatal-loop, was performed. In a first step, we searched for sex-related differences in ADHD patients (N = 137) and separately in healthy controls (HC) (N = 45), after that, we compared an equal group of HC and ADHD patients to compare sex-related differences in ADHD patients and HC. In a second step, we studied whether the neural basis of comorbidity patterns is different between male and female patients. We observed that male ADHD patients demonstrated a decrease in functional connectivity (FC) from the GPe to the left middle temporal gyrus compared to female ADHD patients. Moreover, within the full ADHD group (N = 137), there was a lower FC in male patients from GPe to the right frontal pole/middle frontal gyrus compared to female patients. Male ADHD patients with depression demonstrated decreased FC from the GPe to parts of the occipital cortex compared to female ADHD patients with depression. No such effect was demonstrated for overweight or SUD. The current study reveals different FC profiles in males and females with ADHD, which are centered around altered connectivity with the GPe. An improved understanding of sex-differences in ADHD, and the role of comorbid disorders, therein can result in improved diagnostic and therapeutic opportunities for ADHD patients. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478108/ /pubmed/36117656 http://dx.doi.org/10.3389/fpsyt.2022.962911 Text en Copyright © 2022 Dupont, van Rooij, Buitelaar, Reif and Grimm. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Dupont, Gabriele
van Rooij, Daan
Buitelaar, Jan K.
Reif, Andreas
Grimm, Oliver
Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title_full Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title_fullStr Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title_full_unstemmed Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title_short Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functional MRI
title_sort sex-related differences in adult attention-deficit hyperactivity disorder patients – an analysis of external globus pallidus functional connectivity in resting-state functional mri
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478108/
https://www.ncbi.nlm.nih.gov/pubmed/36117656
http://dx.doi.org/10.3389/fpsyt.2022.962911
work_keys_str_mv AT dupontgabriele sexrelateddifferencesinadultattentiondeficithyperactivitydisorderpatientsananalysisofexternalglobuspallidusfunctionalconnectivityinrestingstatefunctionalmri
AT vanrooijdaan sexrelateddifferencesinadultattentiondeficithyperactivitydisorderpatientsananalysisofexternalglobuspallidusfunctionalconnectivityinrestingstatefunctionalmri
AT buitelaarjank sexrelateddifferencesinadultattentiondeficithyperactivitydisorderpatientsananalysisofexternalglobuspallidusfunctionalconnectivityinrestingstatefunctionalmri
AT reifandreas sexrelateddifferencesinadultattentiondeficithyperactivitydisorderpatientsananalysisofexternalglobuspallidusfunctionalconnectivityinrestingstatefunctionalmri
AT grimmoliver sexrelateddifferencesinadultattentiondeficithyperactivitydisorderpatientsananalysisofexternalglobuspallidusfunctionalconnectivityinrestingstatefunctionalmri