The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure

Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly expresses alternative complement pathway-related genes, including Cfd and C3aR1. Complemen...

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Detalles Bibliográficos
Autores principales: Ito, Shogo, Hashimoto, Hisayuki, Yamakawa, Hiroyuki, Kusumoto, Dai, Akiba, Yohei, Nakamura, Takahiro, Momoi, Mizuki, Komuro, Jin, Katsuki, Toshiomi, Kimura, Mai, Kishino, Yoshikazu, Kashimura, Shin, Kunitomi, Akira, Lachmann, Mark, Shimojima, Masaya, Yozu, Gakuto, Motoda, Chikaaki, Seki, Tomohisa, Yamamoto, Tsunehisa, Shinya, Yoshiki, Hiraide, Takahiro, Kataoka, Masaharu, Kawakami, Takashi, Suzuki, Kunimichi, Ito, Kei, Yada, Hirotaka, Abe, Manabu, Osaka, Mizuko, Tsuru, Hiromi, Yoshida, Masayuki, Sakimura, Kenji, Fukumoto, Yoshihiro, Yuzaki, Michisuke, Fukuda, Keiichi, Yuasa, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478115/
https://www.ncbi.nlm.nih.gov/pubmed/36109509
http://dx.doi.org/10.1038/s41467-022-33152-9

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