Cargando…

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability or hypoxia. Cancer-associated fibroblasts (CAF) are a predominant and heterogeneous population of stromal cells within the pancreatic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mello, Ashley M., Ngodup, Tenzin, Lee, Yusoo, Donahue, Katelyn L., Li, Jinju, Rao, Arvind, Carpenter, Eileen S., Crawford, Howard C., Pasca di Magliano, Marina, Lee, Kyoung Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478137/ https://www.ncbi.nlm.nih.gov/pubmed/36109493 http://dx.doi.org/10.1038/s41389-022-00434-2

Ejemplares similares

Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers
por: Donahue, Katelyn L., et al.
Publicado: (2022)

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1
por: Kemp, Samantha B., et al.
Publicado: (2021)

Myeloid Cell Mediated Ilmmune Suppression in Pancreatic Cancer
por: Kemp, Samantha B., et al.
Publicado: (2021)

WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer
por: Du, Wenting, et al.
Publicado: (2022)

Pancreatic Fibroblast Heterogeneity: From Development to Cancer
por: Garcia, Paloma E., et al.
Publicado: (2020)

Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming
por: Velez-Delgado, Ashley, et al.
Publicado: (2022)

Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer Stroma
por: Garcia, Paloma E., et al.
Publicado: (2020)

Arginase 1 is a key driver of immune suppression in pancreatic cancer
por: Menjivar, Rosa E, et al.
Publicado: (2023)

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages
por: Kemp, Samantha B, et al.
Publicado: (2021)

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer
por: Yan, Wei, et al.
Publicado: (2023)

Tyrosine Sulfation: A New Player and Potential Target in Pancreatic Cancer
por: Zhang, Yaqing, et al.
Publicado: (2023)

Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
por: Brannon, Arthur, et al.
Publicado: (2020)

Kras as a key oncogene and therapeutic target in pancreatic cancer
por: Collins, Meredith A., et al.
Publicado: (2014)

Immune cells in pancreatic cancer: Joining the dark side
por: Zhang, Yaqing, et al.
Publicado: (2014)

3373 Modulation of Hedgehog Signaling Alters Immune Infiltration in Pancreatic Cancer
por: Steele, Nina, et al.
Publicado: (2019)

Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer
por: Du, Wenting, et al.
Publicado: (2021)

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice
por: Zhang, Yaqing, et al.
Publicado: (2017)

Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus
por: Ngodup, Tenzin, et al.
Publicado: (2020)

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis
por: Halbrook, Christopher J., et al.
Publicado: (2016)

The Na(+) leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
por: Ngodup, Tenzin, et al.
Publicado: (2023)

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions
por: Carpenter, Eileen S., et al.
Publicado: (2023)

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis
por: Wen, Hui-Ju, et al.
Publicado: (2019)

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis
por: Hogenson, Tara L., et al.
Publicado: (2016)

Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis
por: Thomas, Marsha M, et al.
Publicado: (2014)

Early pancreatic islet fate and maturation is controlled through RBP-Jκ
por: Cras-Méneur, Corentin, et al.
Publicado: (2016)

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models
por: DeCant, Brian T., et al.
Publicado: (2014)

Change isn't always better
por: Schofield, Heather, et al.
Publicado: (2015)

Stress and suicidal ideation in Korean baby boomers: the mediating effect of mindfulness and meaning in life
por: Jeong, Yusoo
Publicado: (2023)

The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice
por: Hoffman, Megan T., et al.
Publicado: (2020)

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis
por: Wang, Lidong, et al.
Publicado: (2019)

Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth()
por: Pal, Anupama, et al.
Publicado: (2017)

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice
por: Collins, Meredith A., et al.
Publicado: (2012)

Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation()()()
por: Zhang, Qiang, et al.
Publicado: (2016)

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer
por: Zhang, Yaqing, et al.
Publicado: (2017)

KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway
por: Yi, Zhujun, et al.
Publicado: (2021)

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity
por: Hutton, Colin, et al.
Publicado: (2021)

Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer
por: Scales, Michael K., et al.
Publicado: (2022)

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm
por: Schofield, Heather K., et al.
Publicado: (2017)

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
por: Carpenter, Eileen S., et al.
Publicado: (2023)

Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages()()
por: Mathew, Esha, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k6eab43731o9177fscb19len0v