Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expression in the...

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Detalles Bibliográficos
Autores principales: Tonnus, Wulf, Maremonti, Francesca, Belavgeni, Alexia, Latk, Markus, Kusunoki, Yoshihiro, Brucker, Anne, von Mässenhausen, Anne, Meyer, Claudia, Locke, Sophie, Gembardt, Florian, Beer, Kristina, Hoppenz, Paul, Becker, Jan U., Hugo, Christian, Anders, Hans-Joachim, Bornstein, Stefan R., Shao, Feng, Linkermann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478139/
https://www.ncbi.nlm.nih.gov/pubmed/36109515
http://dx.doi.org/10.1038/s41419-022-05230-9

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