Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle wasting in mammals. However, the molecular events that mediate glucocorticoid-induced muscle wasting are not well understood. Here, we show that SIRT6, a chromatin-associated deacetylase indirectly regulates gluco...

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Detalles Bibliográficos
Autores principales: Mishra, Sneha, Cosentino, Claudia, Tamta, Ankit Kumar, Khan, Danish, Srinivasan, Shalini, Ravi, Venkatraman, Abbotto, Elena, Arathi, Bangalore Prabhashankar, Kumar, Shweta, Jain, Aditi, Ramaian, Anand S., Kizkekra, Shruti M., Rajagopal, Raksha, Rao, Swathi, Krishna, Swati, Asirvatham-Jeyaraj, Ninitha, Haggerty, Elizabeth R., Silberman, Dafne M., Kurland, Irwin J., Veeranna, Ravindra P., Jayavelu, Tamilselvan, Bruzzone, Santina, Mostoslavsky, Raul, Sundaresan, Nagalingam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478160/
https://www.ncbi.nlm.nih.gov/pubmed/36109503
http://dx.doi.org/10.1038/s41467-022-32905-w

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