Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases

Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two...

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Autores principales: Lee, Sung Won, Park, Hyun Jung, Van Kaer, Luc, Hong, Seokmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478174/
https://www.ncbi.nlm.nih.gov/pubmed/36119077
http://dx.doi.org/10.3389/fimmu.2022.979370
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author Lee, Sung Won
Park, Hyun Jung
Van Kaer, Luc
Hong, Seokmann
author_facet Lee, Sung Won
Park, Hyun Jung
Van Kaer, Luc
Hong, Seokmann
author_sort Lee, Sung Won
collection PubMed
description Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two decades. In addition, as research on barrier immunity such as the mucosa-associated lymphoid tissue has flourished in recent years, the role of NKT cells to immunity in the skin has attracted substantial attention. Here, we review the contributions of NKT cells to regulating skin inflammation and discuss the factors that can modulate the functions of NKT cells in inflammatory skin diseases such as atopic dermatitis. This mini-review article will mainly focus on CD1d-dependent NKT cells and their therapeutic potential in skin-related immune diseases.
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spelling pubmed-94781742022-09-17 Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases Lee, Sung Won Park, Hyun Jung Van Kaer, Luc Hong, Seokmann Front Immunol Immunology Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two decades. In addition, as research on barrier immunity such as the mucosa-associated lymphoid tissue has flourished in recent years, the role of NKT cells to immunity in the skin has attracted substantial attention. Here, we review the contributions of NKT cells to regulating skin inflammation and discuss the factors that can modulate the functions of NKT cells in inflammatory skin diseases such as atopic dermatitis. This mini-review article will mainly focus on CD1d-dependent NKT cells and their therapeutic potential in skin-related immune diseases. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478174/ /pubmed/36119077 http://dx.doi.org/10.3389/fimmu.2022.979370 Text en Copyright © 2022 Lee, Park, Van Kaer and Hong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lee, Sung Won
Park, Hyun Jung
Van Kaer, Luc
Hong, Seokmann
Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title_full Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title_fullStr Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title_full_unstemmed Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title_short Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
title_sort roles and therapeutic potential of cd1d-restricted nkt cells in inflammatory skin diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478174/
https://www.ncbi.nlm.nih.gov/pubmed/36119077
http://dx.doi.org/10.3389/fimmu.2022.979370
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