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Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients

Constipation has been reported to be more common in patients with mental disorders than in the general population. However, its relationships with psychiatric diagnosis, medication, age, and sex have not been fully identified. A total of 875 patients from the outpatient department were included in t...

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Autores principales: Akasaka, Kuni, Akasaka, Fumi, Akasaka, Tadashi, Okada, Kazutake, Sadahiro, Sotaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478243/
https://www.ncbi.nlm.nih.gov/pubmed/36123894
http://dx.doi.org/10.1097/MD.0000000000030369
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author Akasaka, Kuni
Akasaka, Fumi
Akasaka, Tadashi
Okada, Kazutake
Sadahiro, Sotaro
author_facet Akasaka, Kuni
Akasaka, Fumi
Akasaka, Tadashi
Okada, Kazutake
Sadahiro, Sotaro
author_sort Akasaka, Kuni
collection PubMed
description Constipation has been reported to be more common in patients with mental disorders than in the general population. However, its relationships with psychiatric diagnosis, medication, age, and sex have not been fully identified. A total of 875 patients from the outpatient department were included in the study. As a retrospective observational study, the psychiatric diagnoses and psychotropic medications were examined based on the medical charts. Fecal conditions, including problems with defecation, abdominal pain, sense of incomplete evacuation, use of laxatives, frequency of defecation, and stool characteristics according to the Bristol Scale, were investigated. The study included 368 males and 507 females, with median ages of 48 and 52 years, respectively. The most common psychiatric diagnoses were depressive disorders (33%), followed by anxiety disorders (19%). Females had significantly higher rates of problems with defecation and laxative use than males (P < .001, P < .0001, respectively). The frequency of laxative use increased significantly with age (P < .0001). The multivariate analyses revealed the close relationship between hypnotics and problems of defecation and that between hypnotics, antipsychotics, and laxative use. In psychiatric outpatients, females had significantly higher rates of problems with defecation and laxative use than males. The use of laxatives significantly increased with age. Problems with defecation were significantly more common in patients taking hypnotics and laxative use was significantly more common in patients taking hypnotics and antipsychotics.
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spelling pubmed-94782432022-09-19 Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients Akasaka, Kuni Akasaka, Fumi Akasaka, Tadashi Okada, Kazutake Sadahiro, Sotaro Medicine (Baltimore) Research Article Constipation has been reported to be more common in patients with mental disorders than in the general population. However, its relationships with psychiatric diagnosis, medication, age, and sex have not been fully identified. A total of 875 patients from the outpatient department were included in the study. As a retrospective observational study, the psychiatric diagnoses and psychotropic medications were examined based on the medical charts. Fecal conditions, including problems with defecation, abdominal pain, sense of incomplete evacuation, use of laxatives, frequency of defecation, and stool characteristics according to the Bristol Scale, were investigated. The study included 368 males and 507 females, with median ages of 48 and 52 years, respectively. The most common psychiatric diagnoses were depressive disorders (33%), followed by anxiety disorders (19%). Females had significantly higher rates of problems with defecation and laxative use than males (P < .001, P < .0001, respectively). The frequency of laxative use increased significantly with age (P < .0001). The multivariate analyses revealed the close relationship between hypnotics and problems of defecation and that between hypnotics, antipsychotics, and laxative use. In psychiatric outpatients, females had significantly higher rates of problems with defecation and laxative use than males. The use of laxatives significantly increased with age. Problems with defecation were significantly more common in patients taking hypnotics and laxative use was significantly more common in patients taking hypnotics and antipsychotics. Lippincott Williams & Wilkins 2022-09-16 /pmc/articles/PMC9478243/ /pubmed/36123894 http://dx.doi.org/10.1097/MD.0000000000030369 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Akasaka, Kuni
Akasaka, Fumi
Akasaka, Tadashi
Okada, Kazutake
Sadahiro, Sotaro
Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title_full Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title_fullStr Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title_full_unstemmed Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title_short Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
title_sort relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478243/
https://www.ncbi.nlm.nih.gov/pubmed/36123894
http://dx.doi.org/10.1097/MD.0000000000030369
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