Adipose tissue macrophage in obesity-associated metabolic diseases

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as th...

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Autores principales: Yao, Jingfei, Wu, Dongmei, Qiu, Yifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478335/
https://www.ncbi.nlm.nih.gov/pubmed/36119080
http://dx.doi.org/10.3389/fimmu.2022.977485
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author Yao, Jingfei
Wu, Dongmei
Qiu, Yifu
author_facet Yao, Jingfei
Wu, Dongmei
Qiu, Yifu
author_sort Yao, Jingfei
collection PubMed
description Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as the crosstalk between ATM and adipocyte in thermogenesis, obesity, insulin resistance and adipose tissue fibrosis have been reviewed. A better understanding of how ATM regulates adipose tissue remodeling may provide novel therapeutic strategies against obesity and associated metabolic diseases.
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spelling pubmed-94783352022-09-17 Adipose tissue macrophage in obesity-associated metabolic diseases Yao, Jingfei Wu, Dongmei Qiu, Yifu Front Immunol Immunology Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as the crosstalk between ATM and adipocyte in thermogenesis, obesity, insulin resistance and adipose tissue fibrosis have been reviewed. A better understanding of how ATM regulates adipose tissue remodeling may provide novel therapeutic strategies against obesity and associated metabolic diseases. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478335/ /pubmed/36119080 http://dx.doi.org/10.3389/fimmu.2022.977485 Text en Copyright © 2022 Yao, Wu and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yao, Jingfei
Wu, Dongmei
Qiu, Yifu
Adipose tissue macrophage in obesity-associated metabolic diseases
title Adipose tissue macrophage in obesity-associated metabolic diseases
title_full Adipose tissue macrophage in obesity-associated metabolic diseases
title_fullStr Adipose tissue macrophage in obesity-associated metabolic diseases
title_full_unstemmed Adipose tissue macrophage in obesity-associated metabolic diseases
title_short Adipose tissue macrophage in obesity-associated metabolic diseases
title_sort adipose tissue macrophage in obesity-associated metabolic diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478335/
https://www.ncbi.nlm.nih.gov/pubmed/36119080
http://dx.doi.org/10.3389/fimmu.2022.977485
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AT wudongmei adiposetissuemacrophageinobesityassociatedmetabolicdiseases
AT qiuyifu adiposetissuemacrophageinobesityassociatedmetabolicdiseases

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