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Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle

The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA stabilization and translational regulation. According to their different cellular localization, hnRNPs display multiple functio...

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Autores principales: Wang, Jingming, Sun, Di, Wang, Mingshu, Cheng, Anchun, Zhu, Yukun, Mao, Sai, Ou, Xuming, Zhao, Xinxin, Huang, Juan, Gao, Qun, Zhang, Shaqiu, Yang, Qiao, Wu, Ying, Zhu, Dekang, Jia, Renyong, Chen, Shun, Liu, Mafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478383/
https://www.ncbi.nlm.nih.gov/pubmed/36119073
http://dx.doi.org/10.3389/fimmu.2022.989298
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author Wang, Jingming
Sun, Di
Wang, Mingshu
Cheng, Anchun
Zhu, Yukun
Mao, Sai
Ou, Xuming
Zhao, Xinxin
Huang, Juan
Gao, Qun
Zhang, Shaqiu
Yang, Qiao
Wu, Ying
Zhu, Dekang
Jia, Renyong
Chen, Shun
Liu, Mafeng
author_facet Wang, Jingming
Sun, Di
Wang, Mingshu
Cheng, Anchun
Zhu, Yukun
Mao, Sai
Ou, Xuming
Zhao, Xinxin
Huang, Juan
Gao, Qun
Zhang, Shaqiu
Yang, Qiao
Wu, Ying
Zhu, Dekang
Jia, Renyong
Chen, Shun
Liu, Mafeng
author_sort Wang, Jingming
collection PubMed
description The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA stabilization and translational regulation. According to their different cellular localization, hnRNPs display multiple functions. Most hnRNPs were predominantly located in the nucleus, but some of them could redistribute to the cytoplasm during virus infection. HnRNPs consist of different domains and motifs that enable these proteins to recognize predetermined nucleotide sequences. In the virus-host interactions, hnRNPs specifically bind to viral RNA or proteins. And some of the viral protein-hnRNP interactions require the viral RNA or other host factors as the intermediate. Through various mechanisms, hnRNPs could regulate viral translation, viral genome replication, the switch of translation to replication and virion release. This review highlights the common features and the distinguish roles of hnRNPs in the life cycle of positive single-stranded RNA viruses.
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spelling pubmed-94783832022-09-17 Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle Wang, Jingming Sun, Di Wang, Mingshu Cheng, Anchun Zhu, Yukun Mao, Sai Ou, Xuming Zhao, Xinxin Huang, Juan Gao, Qun Zhang, Shaqiu Yang, Qiao Wu, Ying Zhu, Dekang Jia, Renyong Chen, Shun Liu, Mafeng Front Immunol Immunology The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA stabilization and translational regulation. According to their different cellular localization, hnRNPs display multiple functions. Most hnRNPs were predominantly located in the nucleus, but some of them could redistribute to the cytoplasm during virus infection. HnRNPs consist of different domains and motifs that enable these proteins to recognize predetermined nucleotide sequences. In the virus-host interactions, hnRNPs specifically bind to viral RNA or proteins. And some of the viral protein-hnRNP interactions require the viral RNA or other host factors as the intermediate. Through various mechanisms, hnRNPs could regulate viral translation, viral genome replication, the switch of translation to replication and virion release. This review highlights the common features and the distinguish roles of hnRNPs in the life cycle of positive single-stranded RNA viruses. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478383/ /pubmed/36119073 http://dx.doi.org/10.3389/fimmu.2022.989298 Text en Copyright © 2022 Wang, Sun, Wang, Cheng, Zhu, Mao, Ou, Zhao, Huang, Gao, Zhang, Yang, Wu, Zhu, Jia, Chen and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Jingming
Sun, Di
Wang, Mingshu
Cheng, Anchun
Zhu, Yukun
Mao, Sai
Ou, Xuming
Zhao, Xinxin
Huang, Juan
Gao, Qun
Zhang, Shaqiu
Yang, Qiao
Wu, Ying
Zhu, Dekang
Jia, Renyong
Chen, Shun
Liu, Mafeng
Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title_full Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title_fullStr Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title_full_unstemmed Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title_short Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle
title_sort multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded rna virus life cycle
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478383/
https://www.ncbi.nlm.nih.gov/pubmed/36119073
http://dx.doi.org/10.3389/fimmu.2022.989298
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