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Cyclin-dependent kinase-mediated phosphorylation and the negative regulatory domain of transcription factor B-Myb modulate its DNA binding

B-Myb is a highly conserved member of the vertebrate Myb family of transcription factors that plays a critical role in cell-cycle progression and proliferation. Myb proteins activate Myb-dependent promoters by interacting specifically with Myb-binding site (MBS) sequences using their DNA-binding dom...

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Detalles Bibliográficos
Autores principales: Wijeratne, Tilini U., Guiley, Keelan Z., Lee, Hsiau-Wei, Müller, Gerd A., Rubin, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478404/
https://www.ncbi.nlm.nih.gov/pubmed/35926712
http://dx.doi.org/10.1016/j.jbc.2022.102319