Cargando…
Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer
PURPOSE: The relationship between microsatellite instability (MSI) and tumor response after neoadjuvant chemoradiotherapy (nCRT) in rectal cancer remains unclear. The present study aimed to evaluate the association between MSI and tumor response to nCRT in rectal cancer treatment. METHODS: Patients...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478427/ https://www.ncbi.nlm.nih.gov/pubmed/36128037 http://dx.doi.org/10.4174/astr.2022.103.3.176 |
_version_ | 1784790569799647232 |
---|---|
author | Lee, Soo Young Kim, Duck-Woo Lee, Jaram Park, Hyeong-min Kim, Chang Hyun Lee, Kyung-Hwa Oh, Heung-Kwon Kang, Sung-Bum Kim, Hyeong Rok |
author_facet | Lee, Soo Young Kim, Duck-Woo Lee, Jaram Park, Hyeong-min Kim, Chang Hyun Lee, Kyung-Hwa Oh, Heung-Kwon Kang, Sung-Bum Kim, Hyeong Rok |
author_sort | Lee, Soo Young |
collection | PubMed |
description | PURPOSE: The relationship between microsatellite instability (MSI) and tumor response after neoadjuvant chemoradiotherapy (nCRT) in rectal cancer remains unclear. The present study aimed to evaluate the association between MSI and tumor response to nCRT in rectal cancer treatment. METHODS: Patients with rectal cancer from 2 tertiary hospitals who underwent nCRT, followed by radical surgery, were included. The microsatellite status was determined using a PCR-based Bethesda panel. Tumors with a Dworak’s tumor regression grade of 3 or 4 were considered to have a good response. Predictive factors for a good response to nCRT were analyzed. RESULTS: Of the 1,401 patients included, 910 (65.0%) had MSI results and 1.5% (14 of 910) showed MSI-H. Among all the patients, 519 (37.0%) showed a good response to nCRT. A univariate analysis showed that MSI-H tended to be negatively associated with a good response to nCRT, but no statistical significance was observed (7.1% vs. 24.1%, P = 0.208). Multivariate analysis showed that well-differentiated tumors were the only predictive factor for good response to nCRT (odds ratio [OR], 2.241; 95% confidence interval [CI], 1.492–3.364; P < 0.001). MSI status tended to be associated with the response to nCRT (OR, 0.215; 95% CI, 0.027–1.681; P = 0.143). CONCLUSION: MSI-H was not associated with response to nCRT in patients with rectal cancer. |
format | Online Article Text |
id | pubmed-9478427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94784272022-09-19 Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer Lee, Soo Young Kim, Duck-Woo Lee, Jaram Park, Hyeong-min Kim, Chang Hyun Lee, Kyung-Hwa Oh, Heung-Kwon Kang, Sung-Bum Kim, Hyeong Rok Ann Surg Treat Res Original Article PURPOSE: The relationship between microsatellite instability (MSI) and tumor response after neoadjuvant chemoradiotherapy (nCRT) in rectal cancer remains unclear. The present study aimed to evaluate the association between MSI and tumor response to nCRT in rectal cancer treatment. METHODS: Patients with rectal cancer from 2 tertiary hospitals who underwent nCRT, followed by radical surgery, were included. The microsatellite status was determined using a PCR-based Bethesda panel. Tumors with a Dworak’s tumor regression grade of 3 or 4 were considered to have a good response. Predictive factors for a good response to nCRT were analyzed. RESULTS: Of the 1,401 patients included, 910 (65.0%) had MSI results and 1.5% (14 of 910) showed MSI-H. Among all the patients, 519 (37.0%) showed a good response to nCRT. A univariate analysis showed that MSI-H tended to be negatively associated with a good response to nCRT, but no statistical significance was observed (7.1% vs. 24.1%, P = 0.208). Multivariate analysis showed that well-differentiated tumors were the only predictive factor for good response to nCRT (odds ratio [OR], 2.241; 95% confidence interval [CI], 1.492–3.364; P < 0.001). MSI status tended to be associated with the response to nCRT (OR, 0.215; 95% CI, 0.027–1.681; P = 0.143). CONCLUSION: MSI-H was not associated with response to nCRT in patients with rectal cancer. The Korean Surgical Society 2022-09 2022-09-06 /pmc/articles/PMC9478427/ /pubmed/36128037 http://dx.doi.org/10.4174/astr.2022.103.3.176 Text en Copyright © 2022, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Soo Young Kim, Duck-Woo Lee, Jaram Park, Hyeong-min Kim, Chang Hyun Lee, Kyung-Hwa Oh, Heung-Kwon Kang, Sung-Bum Kim, Hyeong Rok Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title | Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title_full | Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title_fullStr | Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title_full_unstemmed | Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title_short | Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
title_sort | association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478427/ https://www.ncbi.nlm.nih.gov/pubmed/36128037 http://dx.doi.org/10.4174/astr.2022.103.3.176 |
work_keys_str_mv | AT leesooyoung associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT kimduckwoo associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT leejaram associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT parkhyeongmin associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT kimchanghyun associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT leekyunghwa associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT ohheungkwon associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT kangsungbum associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer AT kimhyeongrok associationbetweenmicrosatelliteinstabilityandtumorresponsetoneoadjuvantchemoradiotherapyforrectalcancer |