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Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two bla(KPC-2) gene copies without losing carbapenem resistance

Ceftazidime/Avibactam (CAZ/AVI) is frequently used to treat KPC-producing Pseudomonas aeruginosa (KPC-PA) and Enterobacterales. CAZ/AVI resistance is driven by several mechanisms. In P. aeruginosa this mainly occurs through alteration of AmpC, porins, and/or efflux pump overexpression, whereas in En...

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Detalles Bibliográficos
Autores principales:	García, Patricia, Brito, Bárbara, Alcalde-Rico, Manuel, Munita, José M., Martínez, Jose R. W., Olivares-Pacheco, Jorge, Quiroz, Valeria, Wozniak, Aniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478442/ https://www.ncbi.nlm.nih.gov/pubmed/36118031 http://dx.doi.org/10.3389/fcimb.2022.981792

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