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Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals. Foremost, the physiological α-cleavage of PrP interrupts a region critical for both toxicity and conversion of cellular PrP (PrP(C))...

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Detalles Bibliográficos
Autores principales:	Mays, Charles E., Trinh, Trang H. T., Telling, Glenn, Kang, Hae-Eun, Ryou, Chongsuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478470/ https://www.ncbi.nlm.nih.gov/pubmed/36117913 http://dx.doi.org/10.3389/fnmol.2022.990136

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