The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

Junctional epithelium (JE) is a vital epithelial component which forms an attachment to the tooth surface at the gingival sulcus by the adhesion of protein complexes from its basal layer. Disruption of the JE is associated with the development of gingivitis, periodontal disease, and alveolar bone lo...

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Autores principales: Zhu, Sipin, Xiang, Chuan, Charlesworth, Oscar, Bennett, Samuel, Zhang, Sijuan, Zhou, Maio, Kujan, Omar, Xu, Jiake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478555/
https://www.ncbi.nlm.nih.gov/pubmed/36117697
http://dx.doi.org/10.3389/fphys.2022.1003931
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author Zhu, Sipin
Xiang, Chuan
Charlesworth, Oscar
Bennett, Samuel
Zhang, Sijuan
Zhou, Maio
Kujan, Omar
Xu, Jiake
author_facet Zhu, Sipin
Xiang, Chuan
Charlesworth, Oscar
Bennett, Samuel
Zhang, Sijuan
Zhou, Maio
Kujan, Omar
Xu, Jiake
author_sort Zhu, Sipin
collection PubMed
description Junctional epithelium (JE) is a vital epithelial component which forms an attachment to the tooth surface at the gingival sulcus by the adhesion of protein complexes from its basal layer. Disruption of the JE is associated with the development of gingivitis, periodontal disease, and alveolar bone loss. Odontogenic ameloblast-associated (ODAM) is comprised of a signal peptide and an ODAM protein with 12 putative glycosylation sites. It is expressed during odontogenesis by maturation stage ameloblasts and is incorporated into the enamel matrix during the formation of outer and surface layer enamel. ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the tooth surface; and is involved with extracellular signalling of WNT and ARHGEF5-RhoA, as well as intracellular signalling of BMP-2-BMPR-IB-ODAM. ODAM is also found to be highly expressed in salivary glands and appears to have implications for the regulation of formation, repair, and regeneration of the JE. Bioinformatics and research data have identified the anti-cancer properties of ODAM, indicating its potential both as a prognostic biomarker and therapeutic target. Understanding the biology of ODAM will help to design therapeutic strategies for periodontal and dental disorders.
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spelling pubmed-94785552022-09-17 The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease Zhu, Sipin Xiang, Chuan Charlesworth, Oscar Bennett, Samuel Zhang, Sijuan Zhou, Maio Kujan, Omar Xu, Jiake Front Physiol Physiology Junctional epithelium (JE) is a vital epithelial component which forms an attachment to the tooth surface at the gingival sulcus by the adhesion of protein complexes from its basal layer. Disruption of the JE is associated with the development of gingivitis, periodontal disease, and alveolar bone loss. Odontogenic ameloblast-associated (ODAM) is comprised of a signal peptide and an ODAM protein with 12 putative glycosylation sites. It is expressed during odontogenesis by maturation stage ameloblasts and is incorporated into the enamel matrix during the formation of outer and surface layer enamel. ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the tooth surface; and is involved with extracellular signalling of WNT and ARHGEF5-RhoA, as well as intracellular signalling of BMP-2-BMPR-IB-ODAM. ODAM is also found to be highly expressed in salivary glands and appears to have implications for the regulation of formation, repair, and regeneration of the JE. Bioinformatics and research data have identified the anti-cancer properties of ODAM, indicating its potential both as a prognostic biomarker and therapeutic target. Understanding the biology of ODAM will help to design therapeutic strategies for periodontal and dental disorders. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478555/ /pubmed/36117697 http://dx.doi.org/10.3389/fphys.2022.1003931 Text en Copyright © 2022 Zhu, Xiang, Charlesworth, Bennett, Zhang, Zhou, Kujan and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhu, Sipin
Xiang, Chuan
Charlesworth, Oscar
Bennett, Samuel
Zhang, Sijuan
Zhou, Maio
Kujan, Omar
Xu, Jiake
The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title_full The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title_fullStr The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title_full_unstemmed The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title_short The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
title_sort versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478555/
https://www.ncbi.nlm.nih.gov/pubmed/36117697
http://dx.doi.org/10.3389/fphys.2022.1003931
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