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The role of the different CD3γ domains in TCR expression and signaling

The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ(—)) show reduced surface TCR expression levels and abolished phorbol ester (PMA)-induced TCR down-regulation. The response to PMA is mediated by a double...

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Detalles Bibliográficos
Autores principales:	Garcillán, Beatriz, Megino, Rebeca F., Herrero-Alonso, Marta, Guardo, Alberto C., Perez-Flores, Veronica, Juraske, Claudia, Idstein, Vincent, Martin-Fernandez, Jose M., Geisler, Carsten, Schamel, Wolfgang W. A., Marin, Ana V., Regueiro, Jose R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478619/ https://www.ncbi.nlm.nih.gov/pubmed/36119034 http://dx.doi.org/10.3389/fimmu.2022.978658

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