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Suppressors of fixation can increase average fitness beyond amplifiers of selection

Evolutionary dynamics on graphs has remarkable features: For example, it has been shown that amplifiers of selection exist that—compared to an unstructured population—increase the fixation probability of advantageous mutations, while they decrease the fixation probability of disadvantageous mutation...

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Autores principales: Sharma, Nikhil, Traulsen, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478682/
https://www.ncbi.nlm.nih.gov/pubmed/36067304
http://dx.doi.org/10.1073/pnas.2205424119
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author Sharma, Nikhil
Traulsen, Arne
author_facet Sharma, Nikhil
Traulsen, Arne
author_sort Sharma, Nikhil
collection PubMed
description Evolutionary dynamics on graphs has remarkable features: For example, it has been shown that amplifiers of selection exist that—compared to an unstructured population—increase the fixation probability of advantageous mutations, while they decrease the fixation probability of disadvantageous mutations. So far, the theoretical literature has focused on the case of a single mutant entering a graph-structured population, asking how the graph affects the probability that a mutant takes over a population and the time until this typically happens. For continuously evolving systems, the more relevant case is that mutants constantly arise in an evolving population. Typically, such mutations occur with a small probability during reproduction events. We thus focus on the low mutation rate limit. The probability distribution for the fitness in this process converges to a steady state at long times. Intuitively, amplifiers of selection are expected to increase the population’s mean fitness in the steady state. Similarly, suppressors of selection are expected to decrease the population’s mean fitness in the steady state. However, we show that another set of graphs, called suppressors of fixation, can attain the highest population mean fitness. The key reason behind this is their ability to efficiently reject deleterious mutants. This illustrates the importance of the deleterious mutant regime for the long-term evolutionary dynamics, something that seems to have been overlooked in the literature so far.
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spelling pubmed-94786822023-03-06 Suppressors of fixation can increase average fitness beyond amplifiers of selection Sharma, Nikhil Traulsen, Arne Proc Natl Acad Sci U S A Biological Sciences Evolutionary dynamics on graphs has remarkable features: For example, it has been shown that amplifiers of selection exist that—compared to an unstructured population—increase the fixation probability of advantageous mutations, while they decrease the fixation probability of disadvantageous mutations. So far, the theoretical literature has focused on the case of a single mutant entering a graph-structured population, asking how the graph affects the probability that a mutant takes over a population and the time until this typically happens. For continuously evolving systems, the more relevant case is that mutants constantly arise in an evolving population. Typically, such mutations occur with a small probability during reproduction events. We thus focus on the low mutation rate limit. The probability distribution for the fitness in this process converges to a steady state at long times. Intuitively, amplifiers of selection are expected to increase the population’s mean fitness in the steady state. Similarly, suppressors of selection are expected to decrease the population’s mean fitness in the steady state. However, we show that another set of graphs, called suppressors of fixation, can attain the highest population mean fitness. The key reason behind this is their ability to efficiently reject deleterious mutants. This illustrates the importance of the deleterious mutant regime for the long-term evolutionary dynamics, something that seems to have been overlooked in the literature so far. National Academy of Sciences 2022-09-06 2022-09-13 /pmc/articles/PMC9478682/ /pubmed/36067304 http://dx.doi.org/10.1073/pnas.2205424119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Sharma, Nikhil
Traulsen, Arne
Suppressors of fixation can increase average fitness beyond amplifiers of selection
title Suppressors of fixation can increase average fitness beyond amplifiers of selection
title_full Suppressors of fixation can increase average fitness beyond amplifiers of selection
title_fullStr Suppressors of fixation can increase average fitness beyond amplifiers of selection
title_full_unstemmed Suppressors of fixation can increase average fitness beyond amplifiers of selection
title_short Suppressors of fixation can increase average fitness beyond amplifiers of selection
title_sort suppressors of fixation can increase average fitness beyond amplifiers of selection
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478682/
https://www.ncbi.nlm.nih.gov/pubmed/36067304
http://dx.doi.org/10.1073/pnas.2205424119
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