Cargando…

Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis

Ginsenoside Rh2 is one of the major bioactive ginsenosides in Panax ginseng. Although Rh2 is known to enhance immune cells activity for treatment of cancer, its anti-inflammatory and neuroprotective effects have yet to be determined. In this study, we investigated the effects of Rh2 on spared nerve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Yuan-Yuan, Cen, Jian-Ke, Song, Hao-Lin, Song, Si-Yuan, Zhang, Zhi-Jun, Lu, Huan-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478689/ https://www.ncbi.nlm.nih.gov/pubmed/36039405 http://dx.doi.org/10.1177/17448069221126078

Ejemplares similares

The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
por: Lin, Yingjia, et al.
Publicado: (2017)

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
por: Chen, Xu-Jia, et al.
Publicado: (2017)

Identification of 20(S)-Ginsenoside Rh2 as a Potential EGFR Tyrosine Kinase Inhibitor
por: Liang, Yuan, et al.
Publicado: (2022)

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells: Ginsenoside Rh3 has anti-colorectal cancer properties
por: Wu, Yingchao, et al.
Publicado: (2023)

TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG
por: Zhang, Zhi-Jun, et al.
Publicado: (2018)

Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway
por: Xu, Xiang, et al.
Publicado: (2020)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

Influence of Ginsenoside Rh2 on Cardiomyocyte Pyroptosis in Rats with Acute Myocardial Infarction
por: Song, Wanmei, et al.
Publicado: (2022)

Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice
por: Hsieh, Yung-Hung, et al.
Publicado: (2018)

Induction of apoptosis in prostate cancer by ginsenoside Rh2
por: Tong-Lin Wu, Tony, et al.
Publicado: (2018)

The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
por: Hu, Qi-rui, et al.
Publicado: (2023)

How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?
por: Zhang, Longyun, et al.
Publicado: (2020)

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway
por: Song, Chao, et al.
Publicado: (2022)

The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation
por: Chen, Fang, et al.
Publicado: (2016)

Neuroinflammation in HIV-Related Neuropathic Pain
por: Lu, Huan-Jun, et al.
Publicado: (2021)

Ginsenoside Rh2 attenuates the progression of non‐small cell lung cancer by sponging miR‐28‐5p/STK4 axis and inactivating Wnt/β‐catenin signaling
por: Ma, Jun, et al.
Publicado: (2023)

20(S)-ginsenoside Rh2 as agent for the treatment of LMN-CRC via regulating epithelial–mesenchymal transition
por: Yuan, Yihang, et al.
Publicado: (2020)

The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity
por: Wang, Yu-Shi, et al.
Publicado: (2017)

Transcriptome Analyses of the Anti-Proliferative Effects of 20(S)-Ginsenoside Rh2 on HepG2 Cells
por: Zhang, Ji, et al.
Publicado: (2019)

Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNK/p53 Pathways
por: Yang, Qi, et al.
Publicado: (2020)

Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway
por: Lin, Ze, et al.
Publicado: (2021)

Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation
por: Wang, Jiawen, et al.
Publicado: (2020)

Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment
por: Gou, Xiao-jun, et al.
Publicado: (2017)

Ginsenoside Rh2 Inhibits Glycolysis through the STAT3/c-MYC Axis in Non-Small-Cell Lung Cancer
por: Sun, Xiaodan, et al.
Publicado: (2021)

Protective action of the ginsenoside Rh3 in a rat myocardial ischemia-reperfusion injury model by inhibition of apoptosis induced via p38 mitogen-activated protein kinase/caspase-3 signaling
por: Cao, Liexiang, et al.
Publicado: (2020)

Neuroprotective effects of ginsenosides Rh(1 )and Rg(2 )on neuronal cells
por: Li, Xiao-Fan, et al.
Publicado: (2011)

Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2
por: Popov, Alexander, et al.
Publicado: (2022)

Structure Modification of Ginsenoside Rh(2) and Cytostatic Activity on Cancer Cells
por: Liang, Junyu, et al.
Publicado: (2023)

Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling
por: Jiang, Ruiyuan, et al.
Publicado: (2023)

Ginsenoside Rh1 inhibits colorectal cancer cell migration and invasion in vitro and tumor growth in vivo
por: Lyu, Xi, et al.
Publicado: (2019)

Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation
por: Mathiyalagan, Ramya, et al.
Publicado: (2019)

Ginsenoside Rh2 pretreatment and withdrawal reactivated the pentose phosphate pathway to ameliorate intracellular redox disturbance and promoted intratumoral penetration of adriamycin
por: Liu, Jiali, et al.
Publicado: (2020)

Reversal effect of ginsenoside Rh2 on oxaliplatin-resistant colon cancer cells and its mechanism
por: Ma, Jun, et al.
Publicado: (2019)

Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-κB pathway
por: Bai, Hualei, et al.
Publicado: (2021)

AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2
por: Kim, Min-Jung, et al.
Publicado: (2013)

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase
por: Yang, Jianjun, et al.
Publicado: (2016)

Comparative Pharmacokinetics of Ginsenoside Rg(3) and Ginsenoside Rh(2) after Oral Administration of Ginsenoside Rg(3) in Normal and Walker 256 Tumor-bearing Rats
por: Fan, He, et al.
Publicado: (2016)

Pseudo-Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway
por: Wang, Yuchen, et al.
Publicado: (2018)

Evaluation of the Anti-Inflammatory Pain Effect of Ginsenoside-Conjugated O-Carboxymethyl Chitosan Particles
por: Lu, Huan-Jun, et al.
Publicado: (2023)

Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
por: Yang, Wenqi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_h434p0ak7k9vfic7li16trm74p