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Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

Objective and aims: Osteopontin (OPN), an oxidant stress sensitive cytokine, plays a central role in liver fibrosis. While OPN expression can be reduced by small interfering RNA (siRNA), the challenge to deliver siRNA safely and effectively into liver remains unresolved. Exosomes are promising natur...

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Detalles Bibliográficos
Autores principales:	Tang, Min, Guo, Cheng, Sun, Mengxue, Zhou, Hao, Peng, Xin, Dai, Jianli, Ding, Qin, Wang, Ying, Yang, Changqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478741/ https://www.ncbi.nlm.nih.gov/pubmed/36120332 http://dx.doi.org/10.3389/fphar.2022.882243

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