Cargando…

Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review

INTRODUCTION: Despite the accessibility of several live attenuated vaccines for animals, currently, there is no licensed vaccine for brucellosis in human populations. Available and confirmed animal vaccines may be harmful and considered inappropriate for humans. Thus, human vaccines for brucellosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Darbandi, Atieh, Alamdary, Shabnam Zeighamy, Koupaei, Maryam, Ghanavati, Roya, Heidary, Mohsen, Talebi, Malihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478790/
https://www.ncbi.nlm.nih.gov/pubmed/36118342
http://dx.doi.org/10.3389/fvets.2022.903890
_version_ 1784790652042608640
author Darbandi, Atieh
Alamdary, Shabnam Zeighamy
Koupaei, Maryam
Ghanavati, Roya
Heidary, Mohsen
Talebi, Malihe
author_facet Darbandi, Atieh
Alamdary, Shabnam Zeighamy
Koupaei, Maryam
Ghanavati, Roya
Heidary, Mohsen
Talebi, Malihe
author_sort Darbandi, Atieh
collection PubMed
description INTRODUCTION: Despite the accessibility of several live attenuated vaccines for animals, currently, there is no licensed vaccine for brucellosis in human populations. Available and confirmed animal vaccines may be harmful and considered inappropriate for humans. Thus, human vaccines for brucellosis are required. We aimed to evaluate the effects of Brucella vaccines on mouse models and discuss the potential mechanisms of these vaccines for the design of the appropriate human vaccines. MATERIALS AND METHODS: A systematic search was carried out in Web of Science, Embase, and PubMed/Medline databases. The following MeSH terms were applied: brucellosis, vaccine, Brucella, and vaccination. The original manuscripts describing the Brucella vaccines on mouse models were included. The review articles, editorials, correspondences, case reports, case series, duplicate publications, and articles with insufficient data were excluded. RESULTS: Of the 163 full texts that were screened, 17 articles reached to inclusion criteria. Combining the results of these trials revealed a reduction in bacterial load and colonization rate of Brucella in the spleen, an increase in inflammatory markers, especially IFN-γ and IL-4, and the highest levels of antibody classes in vaccinated animals compared to animals challenged with various virulent strains of Brucella. The majority of studies found that different anti-Brucella vaccines induced a significant protective effect in animals challenged with Brucella strains. Additionally, mice were given the highest level of Brucella vaccine protection and significant clearance of Brucella strains when the immunization was delivered via the IP (intraperitoneal) or IP-IN (intranasal) routes. CONCLUSION: Brucella is responsible for half-million new cases globally annually, and the lack of a proper human vaccine poses the risk of brucellosis. A variety of vaccines are used to prevent brucellosis. Subunit vaccines and recombinant human vaccines have higher safety and protective properties. Although vaccination helps brucellosis control, it does not eradicate the disease. Thus, we recommend the following strategies. (a) establishment of a registration system; (b) close monitoring of slaughterhouses, markets, and herds; (c) training veterinarians; (d) legal protection of the consequences of non-compliance with preventive measures.
format Online
Article
Text
id pubmed-9478790
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94787902022-09-17 Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review Darbandi, Atieh Alamdary, Shabnam Zeighamy Koupaei, Maryam Ghanavati, Roya Heidary, Mohsen Talebi, Malihe Front Vet Sci Veterinary Science INTRODUCTION: Despite the accessibility of several live attenuated vaccines for animals, currently, there is no licensed vaccine for brucellosis in human populations. Available and confirmed animal vaccines may be harmful and considered inappropriate for humans. Thus, human vaccines for brucellosis are required. We aimed to evaluate the effects of Brucella vaccines on mouse models and discuss the potential mechanisms of these vaccines for the design of the appropriate human vaccines. MATERIALS AND METHODS: A systematic search was carried out in Web of Science, Embase, and PubMed/Medline databases. The following MeSH terms were applied: brucellosis, vaccine, Brucella, and vaccination. The original manuscripts describing the Brucella vaccines on mouse models were included. The review articles, editorials, correspondences, case reports, case series, duplicate publications, and articles with insufficient data were excluded. RESULTS: Of the 163 full texts that were screened, 17 articles reached to inclusion criteria. Combining the results of these trials revealed a reduction in bacterial load and colonization rate of Brucella in the spleen, an increase in inflammatory markers, especially IFN-γ and IL-4, and the highest levels of antibody classes in vaccinated animals compared to animals challenged with various virulent strains of Brucella. The majority of studies found that different anti-Brucella vaccines induced a significant protective effect in animals challenged with Brucella strains. Additionally, mice were given the highest level of Brucella vaccine protection and significant clearance of Brucella strains when the immunization was delivered via the IP (intraperitoneal) or IP-IN (intranasal) routes. CONCLUSION: Brucella is responsible for half-million new cases globally annually, and the lack of a proper human vaccine poses the risk of brucellosis. A variety of vaccines are used to prevent brucellosis. Subunit vaccines and recombinant human vaccines have higher safety and protective properties. Although vaccination helps brucellosis control, it does not eradicate the disease. Thus, we recommend the following strategies. (a) establishment of a registration system; (b) close monitoring of slaughterhouses, markets, and herds; (c) training veterinarians; (d) legal protection of the consequences of non-compliance with preventive measures. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478790/ /pubmed/36118342 http://dx.doi.org/10.3389/fvets.2022.903890 Text en Copyright © 2022 Darbandi, Alamdary, Koupaei, Ghanavati, Heidary and Talebi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Darbandi, Atieh
Alamdary, Shabnam Zeighamy
Koupaei, Maryam
Ghanavati, Roya
Heidary, Mohsen
Talebi, Malihe
Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title_full Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title_fullStr Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title_full_unstemmed Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title_short Evaluation of immune responses to Brucella vaccines in mouse models: A systematic review
title_sort evaluation of immune responses to brucella vaccines in mouse models: a systematic review
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478790/
https://www.ncbi.nlm.nih.gov/pubmed/36118342
http://dx.doi.org/10.3389/fvets.2022.903890
work_keys_str_mv AT darbandiatieh evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview
AT alamdaryshabnamzeighamy evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview
AT koupaeimaryam evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview
AT ghanavatiroya evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview
AT heidarymohsen evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview
AT talebimalihe evaluationofimmuneresponsestobrucellavaccinesinmousemodelsasystematicreview