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Expression pattern of non-coding RNAs in non-functioning pituitary adenoma

Non-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies hav...

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Autores principales: Ghafouri-Fard, Soudeh, Safarzadeh, Arash, Akhavan-Bahabadi, Mehdi, Hussen, Bashdar Mahmud, Taheri, Mohammad, Dilmaghani, Nader Akbari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478794/
https://www.ncbi.nlm.nih.gov/pubmed/36119500
http://dx.doi.org/10.3389/fonc.2022.978016
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author Ghafouri-Fard, Soudeh
Safarzadeh, Arash
Akhavan-Bahabadi, Mehdi
Hussen, Bashdar Mahmud
Taheri, Mohammad
Dilmaghani, Nader Akbari
author_facet Ghafouri-Fard, Soudeh
Safarzadeh, Arash
Akhavan-Bahabadi, Mehdi
Hussen, Bashdar Mahmud
Taheri, Mohammad
Dilmaghani, Nader Akbari
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Non-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies have indicated abnormal expression of genes in these tumors. In the current study, we have used existing methods to identify differentially expressed genes (DEGs) including DE long non-coding RNAs (DElncRNAs) and DE microRNAs (DEmiRNAs) in NFPAs compared with normal samples. Then, we have assessed the relation between these genes and important signaling pathways. Our analyses led to identification of 3131 DEGs, including 189 downregulated DEGs (such as RPS4Y1 and DDX3Y) and 2898 upregulated DEGs (such as ASB3 and DRD4), and 44 DElncRNAs, including 8 downregulated DElncRNAs (such as NUTM2B-AS1 and MALAT1) and 36 upregulated DElncRNAs (such as BCAR4 and SRD5A3-AS1). GnRH signaling pathway, Tight junction, Gap junction, Melanogenesis, DNA replication, Nucleotide excision repair, Mismatch repair and N-Glycan biosynthesis have been among dysregulated pathways in NFPAs. Taken together, our study has revealed differential expression of several genes and signaling pathways in this type of tumors.
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spelling pubmed-94787942022-09-17 Expression pattern of non-coding RNAs in non-functioning pituitary adenoma Ghafouri-Fard, Soudeh Safarzadeh, Arash Akhavan-Bahabadi, Mehdi Hussen, Bashdar Mahmud Taheri, Mohammad Dilmaghani, Nader Akbari Front Oncol Oncology Non-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies have indicated abnormal expression of genes in these tumors. In the current study, we have used existing methods to identify differentially expressed genes (DEGs) including DE long non-coding RNAs (DElncRNAs) and DE microRNAs (DEmiRNAs) in NFPAs compared with normal samples. Then, we have assessed the relation between these genes and important signaling pathways. Our analyses led to identification of 3131 DEGs, including 189 downregulated DEGs (such as RPS4Y1 and DDX3Y) and 2898 upregulated DEGs (such as ASB3 and DRD4), and 44 DElncRNAs, including 8 downregulated DElncRNAs (such as NUTM2B-AS1 and MALAT1) and 36 upregulated DElncRNAs (such as BCAR4 and SRD5A3-AS1). GnRH signaling pathway, Tight junction, Gap junction, Melanogenesis, DNA replication, Nucleotide excision repair, Mismatch repair and N-Glycan biosynthesis have been among dysregulated pathways in NFPAs. Taken together, our study has revealed differential expression of several genes and signaling pathways in this type of tumors. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478794/ /pubmed/36119500 http://dx.doi.org/10.3389/fonc.2022.978016 Text en Copyright © 2022 Ghafouri-Fard, Safarzadeh, Akhavan-Bahabadi, Hussen, Taheri and Dilmaghani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Safarzadeh, Arash
Akhavan-Bahabadi, Mehdi
Hussen, Bashdar Mahmud
Taheri, Mohammad
Dilmaghani, Nader Akbari
Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title_full Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title_fullStr Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title_full_unstemmed Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title_short Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
title_sort expression pattern of non-coding rnas in non-functioning pituitary adenoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478794/
https://www.ncbi.nlm.nih.gov/pubmed/36119500
http://dx.doi.org/10.3389/fonc.2022.978016
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