Cargando…

Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study

BACKGROUND: Recently, the new World Health Organization (WHO) tumor classification removed adenocarcinoma in situ (AIS) from the diagnosis of lung cancer. However, it remains unclear whether the “malignancy” item should be assessed when the modified Caprini Risk Assessment Model (RAM) is used to ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Yong-sheng, Dong, Hong-hong, Li, Xin-yang, Ye, Xin, Chen, Shuo, Hu, Bin, Li, Hui, Miao, Jin-bai, Chen, Qi-rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478866/
https://www.ncbi.nlm.nih.gov/pubmed/36119540
http://dx.doi.org/10.3389/fonc.2022.976988
_version_ 1784790669697482752
author Cai, Yong-sheng
Dong, Hong-hong
Li, Xin-yang
Ye, Xin
Chen, Shuo
Hu, Bin
Li, Hui
Miao, Jin-bai
Chen, Qi-rui
author_facet Cai, Yong-sheng
Dong, Hong-hong
Li, Xin-yang
Ye, Xin
Chen, Shuo
Hu, Bin
Li, Hui
Miao, Jin-bai
Chen, Qi-rui
author_sort Cai, Yong-sheng
collection PubMed
description BACKGROUND: Recently, the new World Health Organization (WHO) tumor classification removed adenocarcinoma in situ (AIS) from the diagnosis of lung cancer. However, it remains unclear whether the “malignancy” item should be assessed when the modified Caprini Risk Assessment Model (RAM) is used to assess venous thromboembolism (VTE) risk in AIS. The purpose of our study is to assess differences between AIS and stage IA adenocarcinoma (AD) from a VTE perspective. METHODS: A retrospective study was performed on AIS and IA adenocarcinoma in our hospital from January 2018 to December 2021, and divided into AIS group and AD group. Propensity score matching (PSM) was used to compare the incidence of VTE and coagulation function, and to analyze whether the RAM is more effective when the “malignancy” item is not evaluated in AIS. RESULTS: 491 patients were included after screening, including 104 patients in the AIS group and 387 patients in the AD group. After PSM, 83 patients were matched. The incidence of VTE and D-dimer in the AIS group was significantly lower than that in the AD group (P<0.05).When using the RAM to score AIS, compared with retaining the “malignancy” item, the incidence of VTE in the intermediate-high-risk group was significantly higher after removing the item (7.9% vs. 36.4%, P=0.018), which significantly improved the stratification effect of the model. CONCLUSIONS: The incidence of postoperative VTE in AIS was significantly lower than that in stage IA adenocarcinoma. The stratification effect was more favorable when the “malignancy” item was not evaluated in AIS using the RAM.
format Online
Article
Text
id pubmed-9478866
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94788662022-09-17 Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study Cai, Yong-sheng Dong, Hong-hong Li, Xin-yang Ye, Xin Chen, Shuo Hu, Bin Li, Hui Miao, Jin-bai Chen, Qi-rui Front Oncol Oncology BACKGROUND: Recently, the new World Health Organization (WHO) tumor classification removed adenocarcinoma in situ (AIS) from the diagnosis of lung cancer. However, it remains unclear whether the “malignancy” item should be assessed when the modified Caprini Risk Assessment Model (RAM) is used to assess venous thromboembolism (VTE) risk in AIS. The purpose of our study is to assess differences between AIS and stage IA adenocarcinoma (AD) from a VTE perspective. METHODS: A retrospective study was performed on AIS and IA adenocarcinoma in our hospital from January 2018 to December 2021, and divided into AIS group and AD group. Propensity score matching (PSM) was used to compare the incidence of VTE and coagulation function, and to analyze whether the RAM is more effective when the “malignancy” item is not evaluated in AIS. RESULTS: 491 patients were included after screening, including 104 patients in the AIS group and 387 patients in the AD group. After PSM, 83 patients were matched. The incidence of VTE and D-dimer in the AIS group was significantly lower than that in the AD group (P<0.05).When using the RAM to score AIS, compared with retaining the “malignancy” item, the incidence of VTE in the intermediate-high-risk group was significantly higher after removing the item (7.9% vs. 36.4%, P=0.018), which significantly improved the stratification effect of the model. CONCLUSIONS: The incidence of postoperative VTE in AIS was significantly lower than that in stage IA adenocarcinoma. The stratification effect was more favorable when the “malignancy” item was not evaluated in AIS using the RAM. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9478866/ /pubmed/36119540 http://dx.doi.org/10.3389/fonc.2022.976988 Text en Copyright © 2022 Cai, Dong, Li, Ye, Chen, Hu, Li, Miao and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cai, Yong-sheng
Dong, Hong-hong
Li, Xin-yang
Ye, Xin
Chen, Shuo
Hu, Bin
Li, Hui
Miao, Jin-bai
Chen, Qi-rui
Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title_full Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title_fullStr Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title_full_unstemmed Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title_short Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
title_sort incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified caprini score: a propensity score-matched study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478866/
https://www.ncbi.nlm.nih.gov/pubmed/36119540
http://dx.doi.org/10.3389/fonc.2022.976988
work_keys_str_mv AT caiyongsheng incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT donghonghong incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT lixinyang incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT yexin incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT chenshuo incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT hubin incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT lihui incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT miaojinbai incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy
AT chenqirui incidenceofvenousthromboembolismaftersurgeryforadenocarcinomainsituandthevalidityofthemodifiedcapriniscoreapropensityscorematchedstudy