Cargando…

Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-κB and JAK/STAT signaling pathways and promoting apoptosis

Aconiti Lateralis Radix Praeparata (“Fuzi” in Chinese) is one of the traditional herbs widely used to intervene rheumatoid arthritis (RA), while Fuzi total alkaloids (FTAs) are the main bioactive components. However, the treatment targets and specific mechanisms of FTAs against RA have not been full...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yeke, Liu, Yi, Zhang, Lele, Wen, Lan, Xie, Yunfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478898/ https://www.ncbi.nlm.nih.gov/pubmed/36120302 http://dx.doi.org/10.3389/fphar.2022.980229

Ejemplares similares

Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms
por: Zhang, Wen, et al.
Publicado: (2022)

Simultaneous quantification of nine aconitum alkaloids in Aconiti Lateralis Radix Praeparata and related products using UHPLC–QQQ–MS/MS
por: He, Fan, et al.
Publicado: (2017)

Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata
por: He, Ya-nan, et al.
Publicado: (2018)

Exploration of the Molecular Mechanism of FUZI (Aconiti Lateralis Radix Praeparata) in Allergic Rhinitis Treatment Based on Network Pharmacology
por: Chen, Xiangjing, et al.
Publicado: (2020)

Metabolic Behaviors of Aconitum Alkaloids in Different Concentrations of Aconiti Lateralis Radix Praeparata and Effects of Aconitine in Healthy Human and Long QT Syndrome Cardiomyocytes
por: Yang, Liang, et al.
Publicado: (2022)

Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1
por: Wang, Yutao, et al.
Publicado: (2021)

Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics
por: Xie, Yun-fei, et al.
Publicado: (2019)

Antitumor component recognition from the Aconiti Lateralis Radix Praeparata and Glycyrrhizae Radix et Rhizoma herb pair extract by chemometrics and mean impact value
por: Fan, Hailiu, et al.
Publicado: (2018)

The protective effect and antitumor activity of Aconiti Lateralis Radix Praeparata (Fuzi) polysaccharide on cyclophosphamide-induced immunosuppression in H22 tumor-bearing mice
por: Hu, Qi, et al.
Publicado: (2023)

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp
por: Liu, Weijun, et al.
Publicado: (2021)

HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach
por: Ma, Wenjuan, et al.
Publicado: (2020)

Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids
por: Yang, Mengbi, et al.
Publicado: (2018)

Application of network pharmacology and molecular docking approach to explore active compounds and potential pharmacological mechanisms of Aconiti Lateralis Radix Praeparata and Lepidii Semen Descurainiae Semen for treatment of heart failure
por: Yang, Meng-Qi, et al.
Publicado: (2022)

Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi–Gancao) by UHPLC-ESI-MS/MS
por: Fu, Xiao, et al.
Publicado: (2017)

Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway
por: Yan, Ping, et al.
Publicado: (2020)

Tissue Accumulations of Toxic Aconitum Alkaloids after Short-Term and Long-Term Oral Administrations of Clinically Used Radix Aconiti Lateralis Preparations in Rats
por: Ji, Xiaoyu, et al.
Publicado: (2019)

Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS
por: Yang, Liang, et al.
Publicado: (2018)

Comparative investigation for raw and processed Aconiti Lateralis Radix using chemical UPLC-MS profiling and multivariate classification techniques
por: Sun, Lili, et al.
Publicado: (2018)

An optimized high-performance liquid chromatography (HPLC) method for benzoylmesaconine determination in Radix Aconiti Lateralis Preparata (Fuzi, aconite roots) and its products
por: Xie, Ying, et al.
Publicado: (2008)

Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata
por: Gao, Dan, et al.
Publicado: (2016)

Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis
por: Park, Jinbong, et al.
Publicado: (2019)

Anti-Myocardial Infarction Effects of Radix Aconiti Lateralis Preparata Extracts and Their Influence on Small Molecules in the Heart Using Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging
por: Wu, Hao, et al.
Publicado: (2019)

Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MS/MS
por: Zhi, Meiru, et al.
Publicado: (2020)

Research on the Relationships between Endogenous Biomarkers and Exogenous Toxic Substances of Acute Toxicity in Radix Aconiti
por: Zhou, Haonan, et al.
Publicado: (2016)

Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway
por: Kim, Do Rim, et al.
Publicado: (2013)

Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells
por: Li, Xingyao, et al.
Publicado: (2022)

“Quantity-effect” research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay
por: Li, Hong-Ying, et al.
Publicado: (2020)

Metabolic regulation mechanism of Aconiti Radix Cocta extract in rats based on (1)H-NMR metabonomics
por: Jin, Wenfang, et al.
Publicado: (2022)

Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis
por: Wu, Jiawen, et al.
Publicado: (2023)

Curculigoside exerts significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway
por: Tan, Shirui, et al.
Publicado: (2019)

Traditional Chinese Medicine Aconiti Radix Cocta Improves Rheumatoid Arthritis via Suppressing COX-1 and COX-2
por: Li, Shuang, et al.
Publicado: (2021)

How Aconiti Radix Cocta can Treat Gouty Arthritis Based on Systematic Pharmacology and UPLC-QTOF-MS/MS
por: Ye, Xietao, et al.
Publicado: (2021)

High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (Zhiheshouwu) by UHPLC-Q-Exactive Orbitrap-MS
por: Wang, Shaoyun, et al.
Publicado: (2021)

Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress
por: Feng, Xinzhe, et al.
Publicado: (2020)

Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification
por: Chen, Xi, et al.
Publicado: (2021)

Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer’s disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota
por: Su, Yunfang, et al.
Publicado: (2023)

Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Paeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis
por: Zhang, Yugui, et al.
Publicado: (2022)

Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
por: Ning, Funan, et al.
Publicado: (2021)

Effects of dietary incorporation of Radix rehmanniae praeparata polysaccharide on growth performance, digestive physiology, blood metabolites, meat quality, and tibia characteristics in broiler chickens
por: Yang, Bing, et al.
Publicado: (2023)

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
por: Czerkies, Maciej, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nt0b9kq6813l78ae5nflk5afmm