Swapping N-terminal regions among tick evasins reveals cooperative interactions influencing chemokine binding and selectivity

Class A tick evasins are natural chemokine-binding proteins that block the signaling of multiple chemokines from the CC subfamily through their cognate receptors, thus suppressing leukocyte recruitment and inflammation. Development of tick evasins as chemokine-targeted anti-inflammatory therapeutics...

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Detalles Bibliográficos
Autores principales: Aryal, Pramod, Devkota, Shankar Raj, Jeevarajah, Devadharshini, Law, Ruby, Payne, Richard J., Bhusal, Ram Prasad, Stone, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478924/
https://www.ncbi.nlm.nih.gov/pubmed/35973511
http://dx.doi.org/10.1016/j.jbc.2022.102382

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