Applying a clinical lens to animal models of CAR-T cell therapies

Chimeric antigen receptor (CAR)-T cells have emerged as a promising treatment modality for various hematologic and solid malignancies over the past decade. Animal models remain the cornerstone of pre-clinical evaluation of human CAR-T cell products and are generally required by regulatory agencies p...

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Detalles Bibliográficos
Autores principales: Duncan, Brynn B., Dunbar, Cynthia E., Ishii, Kazusa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478925/
https://www.ncbi.nlm.nih.gov/pubmed/36156878
http://dx.doi.org/10.1016/j.omtm.2022.08.008

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