Cargando…

GANT61 exerts anticancer cell and anticancer stem cell capacity in colorectal cancer by blocking the Wnt/β-catenin and Notch signalling pathways

The present study aimed to assess the anticancer cell and anticancer stem cell (CSC) effects of GANT61, and its regulatory influence on the Wnt/β-catenin and Notch signalling pathways in colorectal cancer (CRC). HT-29 and HCT-116 cells were treated with 0, 2.5, 5, 10, 20 or 40 µM GANT61, after which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Si, Yanhui, Li, Lei, Zhang, Weiwei, Liu, Qiling, Liu, Baochi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478957/ https://www.ncbi.nlm.nih.gov/pubmed/36069229 http://dx.doi.org/10.3892/or.2022.8397

Ejemplares similares

The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells
por: Gonnissen, Annelies, et al.
Publicado: (2017)

Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway
por: Zhang, Qi-Hao, et al.
Publicado: (2019)

GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment
por: Li, Jianlong, et al.
Publicado: (2016)

Antimicrobial agent chloroxylenol targets β-catenin-mediated Wnt signaling and exerts anticancer activity in colorectal cancer
por: Sun, Qi, et al.
Publicado: (2023)

The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK
por: Wang, Jing, et al.
Publicado: (2018)

Evodiamine Exerts Anticancer Effects Against 143B and MG63 Cells Through the Wnt/β-Catenin Signaling Pathway
por: Yang, Shengdong, et al.
Publicado: (2020)

Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells
por: Wang, Jing, et al.
Publicado: (2014)

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
por: Lim, Chuan Bian, et al.
Publicado: (2015)

Wnt/beta-catenin pathway: modulating anticancer immune response
por: Pai, Sachin Gopalkrishna, et al.
Publicado: (2017)

Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells
por: Yu, Shubin, et al.
Publicado: (2018)

Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β-catenin signaling
por: Sun, Qi, et al.
Publicado: (2019)

The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo
por: Gonnissen, Annelies, et al.
Publicado: (2016)

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
por: Calcaterra, Andrea, et al.
Publicado: (2018)

GANT61/BI-847325 combination: a new hope in lung cancer treatment
por: El-Kishky, Abdel Halim M., et al.
Publicado: (2022)

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies
por: Kumar, Vivek, et al.
Publicado: (2021)

GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway
por: Zhang, Zhihua, et al.
Publicado: (2020)

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing
por: Zhang, Ruowen, et al.
Publicado: (2016)

Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality
por: Youssef, Mohamed, et al.
Publicado: (2022)

Anti‐cancer stem cell activity of a hedgehog inhibitor GANT61 in estrogen receptor‐positive breast cancer cells
por: Kurebayashi, Junichi, et al.
Publicado: (2017)

GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells
por: Bacelar Sacramento de Araújo, Taís, et al.
Publicado: (2020)

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition
por: Miyazaki, Yumi, et al.
Publicado: (2016)

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding
por: Agyeman, Akwasi, et al.
Publicado: (2014)

Miss Zilphia Gant
por: Faulkner, William, 1897-1962
Publicado: (1971)

Miss Zilphia Gant
por: Faulkner, William, 1897-1962

Gant on Bladder Diseases
Publicado: (1877)

Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide
por: Majchrzak-Celińska, Aleksandra, et al.
Publicado: (2022)

Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity
por: Kim, Na Young, et al.
Publicado: (2022)

The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation
por: Konings, Katrien, et al.
Publicado: (2019)

Hedgehog Signal Inhibitor GANT61 Inhibits the Malignant Behavior of Undifferentiated Hepatocellular Carcinoma Cells by Targeting Non-Canonical GLI Signaling
por: Harada, Kensuke, et al.
Publicado: (2020)

Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells
por: Lin, Li-Chun, et al.
Publicado: (2018)

GANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma
por: Sun, Yifeng, et al.
Publicado: (2023)

Fray Pedro de Gante
por: Chávez, Ezequiel A., 1868-1946
Publicado: (1962)

Gant's Science and Practice of Surgery
Publicado: (1872)

Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway
por: Wang, Yingying, et al.
Publicado: (2021)

GLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3
por: Geng, Lingyun, et al.
Publicado: (2016)

A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/β‑catenin Signaling
por: He, Liu-Jun, et al.
Publicado: (2020)

Repeated Autologous Bone Marrow Transfusion through Portal Vein for Treating Decompensated Liver Cirrhosis after Splenectomy
por: Zhang, Weiwei, et al.
Publicado: (2018)

Forskolin exerts anticancer roles in non-Hodgkin’s lymphomas via regulating Axin/β-catenin signaling pathway
por: Wang, Hailei, et al.
Publicado: (2019)

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
por: Srivastava, Ritesh K., et al.
Publicado: (2014)

Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
por: He, Cuiying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5005ujcc5itjgo5iaev3cf1q12