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Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells
Genomic instability, a feature of most cancers, contributes to malignant cell transformation and cancer progression due to the accumulation of genetic alterations. Genomic instability is reflected at numerous levels, from single nucleotide to the chromosome levels. However, the exact molecular mecha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478986/ https://www.ncbi.nlm.nih.gov/pubmed/36004472 http://dx.doi.org/10.3892/or.2022.8390 |
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author | Yang, Kai Liang, Xiaoxiang Wen, Kunming |
author_facet | Yang, Kai Liang, Xiaoxiang Wen, Kunming |
author_sort | Yang, Kai |
collection | PubMed |
description | Genomic instability, a feature of most cancers, contributes to malignant cell transformation and cancer progression due to the accumulation of genetic alterations. Genomic instability is reflected at numerous levels, from single nucleotide to the chromosome levels. However, the exact molecular mechanisms and regulators of genomic instability in cancer remain unclear. Growing evidence indicates that the binding of long non-coding RNAs (lncRNAs) to protein chaperones confers a variety of regulatory functions, including managing of genomic instability. The aim of the present review was to examine the roles of mitosis, telomeres, DNA repair, and epigenetics in genomic instability, and the mechanisms by which lncRNAs regulate them by binding proteins in cancer cells. This review contributes to our understanding of the role of lncRNAs and genomic instability in cancer and can potentially provide entry points and molecular targets for cancer therapies. |
format | Online Article Text |
id | pubmed-9478986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-94789862022-10-03 Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells Yang, Kai Liang, Xiaoxiang Wen, Kunming Oncol Rep Review Genomic instability, a feature of most cancers, contributes to malignant cell transformation and cancer progression due to the accumulation of genetic alterations. Genomic instability is reflected at numerous levels, from single nucleotide to the chromosome levels. However, the exact molecular mechanisms and regulators of genomic instability in cancer remain unclear. Growing evidence indicates that the binding of long non-coding RNAs (lncRNAs) to protein chaperones confers a variety of regulatory functions, including managing of genomic instability. The aim of the present review was to examine the roles of mitosis, telomeres, DNA repair, and epigenetics in genomic instability, and the mechanisms by which lncRNAs regulate them by binding proteins in cancer cells. This review contributes to our understanding of the role of lncRNAs and genomic instability in cancer and can potentially provide entry points and molecular targets for cancer therapies. D.A. Spandidos 2022-08-19 /pmc/articles/PMC9478986/ /pubmed/36004472 http://dx.doi.org/10.3892/or.2022.8390 Text en Copyright: © Yang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Yang, Kai Liang, Xiaoxiang Wen, Kunming Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title | Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title_full | Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title_fullStr | Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title_full_unstemmed | Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title_short | Long non-coding RNAs interact with RNA-binding proteins to regulate genomic instability in cancer cells |
title_sort | long non-coding rnas interact with rna-binding proteins to regulate genomic instability in cancer cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478986/ https://www.ncbi.nlm.nih.gov/pubmed/36004472 http://dx.doi.org/10.3892/or.2022.8390 |
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