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tBHQ attenuates podocyte injury in diabetic nephropathy by inhibiting NADPH oxidase-derived ROS generation via the Nrf2/HO-1 signalling pathway

AIMS: Oxidative stress plays a crucial role in podocyte injury in diabetic nephropathy (DN). tert-Butylhydroquinone (tBHQ) is an activator of Nrf2 that exerts protective effects in diabetic mice, but the underlying mechanism of tBHQ in the podocytes of DN is not fully understood. MATERIALS AND METHO...

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Detalles Bibliográficos
Autores principales:	Liu, Ting, Li, Chang-yan, Chen, Hao, Liu, Juan, Zhong, Li-li, Tang, Ming-min, Wang, Wen-bo, Huang, Jin-ping, Jiang, Xu-shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479023/ https://www.ncbi.nlm.nih.gov/pubmed/36119860 http://dx.doi.org/10.1016/j.heliyon.2022.e10515

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