Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Hematopoietic stem cells (HSCs) manifest impaired recovery and self-renewal with a concomitant increase in differentiation when exposed to ambient air as opposed to physioxia. Mechanism(s) behind this distinction are poorly understood but have the potential to improve stem cell transplantation. Sing...

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Detalles Bibliográficos
Autores principales: Aljoufi, Arafat, Zhang, Chi, Ropa, James, Chang, Wennan, Palam, Lakshmi Reddy, Cooper, Scott, Ramdas, Baskar, Capitano, Maegan L., Broxmeyer, Hal E., Kapur, Reuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479026/
https://www.ncbi.nlm.nih.gov/pubmed/35772013
http://dx.doi.org/10.1182/blood.2022015499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479026/
https://www.ncbi.nlm.nih.gov/pubmed/35772013
http://dx.doi.org/10.1182/blood.2022015499

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