Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

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The SARS-CoV-2 main protease (M(pro)) is the drug target of Pfizer’s oral drug Paxlovid. The emergence of SARS-CoV-2 variants with mutations in M(pro) raised the alarm of potential drug resistance. In this study, we identified 100 naturally occurring M(pro) mutations located at the nirmatrelvir bind...

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Detalles Bibliográficos
Autores principales: Hu, Yanmei, Lewandowski, Eric M., Tan, Haozhou, Zhang, Xiaoming, Morgan, Ryan T., Zhang, Xiujun, Jacobs, Lian M. C., Butler, Shane G., Gongora, Maura V., Choy, John, Deng, Xufang, Chen, Yu, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479041/
https://www.ncbi.nlm.nih.gov/pubmed/36119652
http://dx.doi.org/10.1101/2022.06.28.497978
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