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Case report: The MSI-L/p-MMR metastatic rectal cancer patient who failed systemic therapy responds to anti-PD-1 immunotherapy after stereotactic body radiation-therapy

BACKGROUND: Traditionally, patients with microsatellite stability (MSS)/microsatellite instability-Low (MSI-L)/proficient mismatch repair (p-MMR) metastatic colorectal cancer (mCRC) have had poor benefit from immunotherapy. Therefore, how to enhance the response of immunotherapy is still a challenge...

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Detalles Bibliográficos
Autores principales: Liu, Shijin, Zhang, Yiran, Lin, Yujian, Wang, Peize, Pan, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479073/
https://www.ncbi.nlm.nih.gov/pubmed/36119063
http://dx.doi.org/10.3389/fimmu.2022.981527