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Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference

Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total...

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Autores principales: Miyajima, Yuna, Karashima, Shigehiro, Ogai, Kazuhiro, Taniguchi, Kouki, Ogura, Kohei, Kawakami, Masaki, Nambo, Hidetaka, Kometani, Mitsuhiro, Aono, Daisuke, Demura, Masashi, Yoneda, Takashi, Tsujiguchi, Hiromasa, Hara, Akinori, Nakamura, Hiroyuki, Okamoto, Shigefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479221/
https://www.ncbi.nlm.nih.gov/pubmed/36118024
http://dx.doi.org/10.3389/fcimb.2022.908997
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author Miyajima, Yuna
Karashima, Shigehiro
Ogai, Kazuhiro
Taniguchi, Kouki
Ogura, Kohei
Kawakami, Masaki
Nambo, Hidetaka
Kometani, Mitsuhiro
Aono, Daisuke
Demura, Masashi
Yoneda, Takashi
Tsujiguchi, Hiromasa
Hara, Akinori
Nakamura, Hiroyuki
Okamoto, Shigefumi
author_facet Miyajima, Yuna
Karashima, Shigehiro
Ogai, Kazuhiro
Taniguchi, Kouki
Ogura, Kohei
Kawakami, Masaki
Nambo, Hidetaka
Kometani, Mitsuhiro
Aono, Daisuke
Demura, Masashi
Yoneda, Takashi
Tsujiguchi, Hiromasa
Hara, Akinori
Nakamura, Hiroyuki
Okamoto, Shigefumi
author_sort Miyajima, Yuna
collection PubMed
description Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total of 79 men and 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included in the analysis, and their clinical information was investigated. DNA extracted from the GM was processed to sequence the 16S rRNA gene using next-generation sequencing. Participants were divided into four groups based on sex and lipid profile information. The results of one-way analysis of covariance, linear discriminant analysis effect size, and least absolute value reduction and selection operator logistic regression model indicated that several bacteria between men and women may be associated with DL. The LiNGAM showed a presumed causal relationship between different bacteria and lipid profiles in men and women. In men, Prevotella 9 and Bacteroides were shown to be potentially associated with changes in low- and high-density lipoprotein cholesterol levels. In women, the LiNGAM results showed two bacteria, Akkermansia and Escherichia/Shigella, had a presumptive causal relationship with lipid profiles. These results may provide a new sex-based strategy to reduce the risk of developing DL and to treat DL through the regulation of the intestinal environment using specific GM.
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spelling pubmed-94792212022-09-17 Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference Miyajima, Yuna Karashima, Shigehiro Ogai, Kazuhiro Taniguchi, Kouki Ogura, Kohei Kawakami, Masaki Nambo, Hidetaka Kometani, Mitsuhiro Aono, Daisuke Demura, Masashi Yoneda, Takashi Tsujiguchi, Hiromasa Hara, Akinori Nakamura, Hiroyuki Okamoto, Shigefumi Front Cell Infect Microbiol Cellular and Infection Microbiology Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total of 79 men and 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included in the analysis, and their clinical information was investigated. DNA extracted from the GM was processed to sequence the 16S rRNA gene using next-generation sequencing. Participants were divided into four groups based on sex and lipid profile information. The results of one-way analysis of covariance, linear discriminant analysis effect size, and least absolute value reduction and selection operator logistic regression model indicated that several bacteria between men and women may be associated with DL. The LiNGAM showed a presumed causal relationship between different bacteria and lipid profiles in men and women. In men, Prevotella 9 and Bacteroides were shown to be potentially associated with changes in low- and high-density lipoprotein cholesterol levels. In women, the LiNGAM results showed two bacteria, Akkermansia and Escherichia/Shigella, had a presumptive causal relationship with lipid profiles. These results may provide a new sex-based strategy to reduce the risk of developing DL and to treat DL through the regulation of the intestinal environment using specific GM. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9479221/ /pubmed/36118024 http://dx.doi.org/10.3389/fcimb.2022.908997 Text en Copyright © 2022 Miyajima, Karashima, Ogai, Taniguchi, Ogura, Kawakami, Nambo, Kometani, Aono, Demura, Yoneda, Tsujiguchi, Hara, Nakamura and Okamoto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Miyajima, Yuna
Karashima, Shigehiro
Ogai, Kazuhiro
Taniguchi, Kouki
Ogura, Kohei
Kawakami, Masaki
Nambo, Hidetaka
Kometani, Mitsuhiro
Aono, Daisuke
Demura, Masashi
Yoneda, Takashi
Tsujiguchi, Hiromasa
Hara, Akinori
Nakamura, Hiroyuki
Okamoto, Shigefumi
Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title_full Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title_fullStr Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title_full_unstemmed Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title_short Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference
title_sort impact of gut microbiome on dyslipidemia in japanese adults: assessment of the shika-machi super preventive health examination results for causal inference
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479221/
https://www.ncbi.nlm.nih.gov/pubmed/36118024
http://dx.doi.org/10.3389/fcimb.2022.908997
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