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Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study
OBJECTIVE: The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hy...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479233/ https://www.ncbi.nlm.nih.gov/pubmed/36109817 http://dx.doi.org/10.1186/s13104-022-06190-1 |
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author | Nkeck, Jan René Ida, Chemgne Marie Koe, Valerie Ndobo Ndam, Antonin Wilson Ndjitoyap Jessica, Yondo Ndedi Claudine Manuella, Eko Ondoa Charelle, Boukeu Yonta Corine, Zouague Zalbi Andrée, Ntyam Abena Amazia, Falmata Nkeck, Jériel Pascal Samba, Esther Astrid Mbono Moor, Vicky Jocelyne Ama |
author_facet | Nkeck, Jan René Ida, Chemgne Marie Koe, Valerie Ndobo Ndam, Antonin Wilson Ndjitoyap Jessica, Yondo Ndedi Claudine Manuella, Eko Ondoa Charelle, Boukeu Yonta Corine, Zouague Zalbi Andrée, Ntyam Abena Amazia, Falmata Nkeck, Jériel Pascal Samba, Esther Astrid Mbono Moor, Vicky Jocelyne Ama |
author_sort | Nkeck, Jan René |
collection | PubMed |
description | OBJECTIVE: The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlates it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI). RESULTS: We found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p = 0.021], which was dependent of triglycerides levels (r = 0.17; p = 0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied; Although being related to atherogenic risk, as reported in literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population. |
format | Online Article Text |
id | pubmed-9479233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94792332022-09-17 Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study Nkeck, Jan René Ida, Chemgne Marie Koe, Valerie Ndobo Ndam, Antonin Wilson Ndjitoyap Jessica, Yondo Ndedi Claudine Manuella, Eko Ondoa Charelle, Boukeu Yonta Corine, Zouague Zalbi Andrée, Ntyam Abena Amazia, Falmata Nkeck, Jériel Pascal Samba, Esther Astrid Mbono Moor, Vicky Jocelyne Ama BMC Res Notes Research Note OBJECTIVE: The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlates it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI). RESULTS: We found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p = 0.021], which was dependent of triglycerides levels (r = 0.17; p = 0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied; Although being related to atherogenic risk, as reported in literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population. BioMed Central 2022-09-15 /pmc/articles/PMC9479233/ /pubmed/36109817 http://dx.doi.org/10.1186/s13104-022-06190-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Note Nkeck, Jan René Ida, Chemgne Marie Koe, Valerie Ndobo Ndam, Antonin Wilson Ndjitoyap Jessica, Yondo Ndedi Claudine Manuella, Eko Ondoa Charelle, Boukeu Yonta Corine, Zouague Zalbi Andrée, Ntyam Abena Amazia, Falmata Nkeck, Jériel Pascal Samba, Esther Astrid Mbono Moor, Vicky Jocelyne Ama Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title | Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title_full | Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title_fullStr | Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title_full_unstemmed | Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title_short | Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study |
title_sort | gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive cameroonians: preliminary data from hyricca study |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479233/ https://www.ncbi.nlm.nih.gov/pubmed/36109817 http://dx.doi.org/10.1186/s13104-022-06190-1 |
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