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The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis
BACKGROUND: Fibrinogen to albumin ratio (FAR) is a newly investigated indicator for inflammation. The study aimed to explore the potential ability of FAR in assessing the severity of inflammation in spondyloarthritis. METHODS: The clinical data of 196 spondyloarthritis (SpA) patients, 66 osteoarthri...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479360/ https://www.ncbi.nlm.nih.gov/pubmed/36109740 http://dx.doi.org/10.1186/s12891-022-05797-6 |
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author | Ding, Yimei Xue, Luan |
author_facet | Ding, Yimei Xue, Luan |
author_sort | Ding, Yimei |
collection | PubMed |
description | BACKGROUND: Fibrinogen to albumin ratio (FAR) is a newly investigated indicator for inflammation. The study aimed to explore the potential ability of FAR in assessing the severity of inflammation in spondyloarthritis. METHODS: The clinical data of 196 spondyloarthritis (SpA) patients, 66 osteoarthritis (OA) patients, and 81 healthy controls (HC) were collected in this retrospective study. The SpA group included 69 psoriatic arthritis patients, 47 reactive arthritis patients and 80 ankylosing spondylitis patients. Chi-square test and Mann–Whitney U test, Spearman’s correlation test, regression analysis, and ROC analyses were used for the analysis of FAR. RESULTS: FAR level in group SpA was higher than in OA or HC. In the SpA group, the reactive arthritis group was characterized by the highest FAR level. After matching the erythrocyte sedimentation rate, a significant difference occurred between groups SpA and OA, but not in SpA subgroups. The FAR level was significantly related to erythrocyte sedimentation rate and C-reactive protein. After regression and receiver operating characteristics analysis, FAR was considered the most potential pointer to evaluate inflammation in SpA with the area under curve of 0.95. The recommended cut-off value of FAR was 9.44 for serious inflammation and 8.34 for mild conditions. CONCLUSION: FAR is closely related to inflammatory biomarkers and can be a potential indicator in the assessment of inflammation in spondyloarthritis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05797-6. |
format | Online Article Text |
id | pubmed-9479360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94793602022-09-17 The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis Ding, Yimei Xue, Luan BMC Musculoskelet Disord Research BACKGROUND: Fibrinogen to albumin ratio (FAR) is a newly investigated indicator for inflammation. The study aimed to explore the potential ability of FAR in assessing the severity of inflammation in spondyloarthritis. METHODS: The clinical data of 196 spondyloarthritis (SpA) patients, 66 osteoarthritis (OA) patients, and 81 healthy controls (HC) were collected in this retrospective study. The SpA group included 69 psoriatic arthritis patients, 47 reactive arthritis patients and 80 ankylosing spondylitis patients. Chi-square test and Mann–Whitney U test, Spearman’s correlation test, regression analysis, and ROC analyses were used for the analysis of FAR. RESULTS: FAR level in group SpA was higher than in OA or HC. In the SpA group, the reactive arthritis group was characterized by the highest FAR level. After matching the erythrocyte sedimentation rate, a significant difference occurred between groups SpA and OA, but not in SpA subgroups. The FAR level was significantly related to erythrocyte sedimentation rate and C-reactive protein. After regression and receiver operating characteristics analysis, FAR was considered the most potential pointer to evaluate inflammation in SpA with the area under curve of 0.95. The recommended cut-off value of FAR was 9.44 for serious inflammation and 8.34 for mild conditions. CONCLUSION: FAR is closely related to inflammatory biomarkers and can be a potential indicator in the assessment of inflammation in spondyloarthritis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-022-05797-6. BioMed Central 2022-09-15 /pmc/articles/PMC9479360/ /pubmed/36109740 http://dx.doi.org/10.1186/s12891-022-05797-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ding, Yimei Xue, Luan The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title | The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title_full | The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title_fullStr | The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title_full_unstemmed | The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title_short | The potential value of fibrinogen to albumin ratio (FAR) in the assessment of inflammation in spondyloarthritis |
title_sort | potential value of fibrinogen to albumin ratio (far) in the assessment of inflammation in spondyloarthritis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479360/ https://www.ncbi.nlm.nih.gov/pubmed/36109740 http://dx.doi.org/10.1186/s12891-022-05797-6 |
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