CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease

Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further ampli...

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Autores principales: Chang, Ting-Ting, Chen, Ching, Chen, Jaw-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479413/
https://www.ncbi.nlm.nih.gov/pubmed/36109744
http://dx.doi.org/10.1186/s12933-022-01626-1
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author Chang, Ting-Ting
Chen, Ching
Chen, Jaw-Wen
author_facet Chang, Ting-Ting
Chen, Ching
Chen, Jaw-Wen
author_sort Chang, Ting-Ting
collection PubMed
description Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease.
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spelling pubmed-94794132022-09-17 CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease Chang, Ting-Ting Chen, Ching Chen, Jaw-Wen Cardiovasc Diabetol Review Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease. BioMed Central 2022-09-15 /pmc/articles/PMC9479413/ /pubmed/36109744 http://dx.doi.org/10.1186/s12933-022-01626-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chang, Ting-Ting
Chen, Ching
Chen, Jaw-Wen
CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title_full CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title_fullStr CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title_full_unstemmed CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title_short CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
title_sort ccl7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479413/
https://www.ncbi.nlm.nih.gov/pubmed/36109744
http://dx.doi.org/10.1186/s12933-022-01626-1
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