Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury

BACKGROUND: Notch signaling is highly conserved and critically involved in cell differentiation, immunity, and survival. Activation of the Notch pathway modulates immune cell functions during the inflammatory response. However, it remains unknown whether and how the macrophage Notch1 may control the...

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Detalles Bibliográficos
Autores principales: Xu, Dongwei, Qu, Xiaoye, Tian, Yizhu, Jie, Zhao, Xi, Zhifeng, Xue, Feng, Ma, Xueyun, Zhu, Jianjun, Xia, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479434/
https://www.ncbi.nlm.nih.gov/pubmed/36114543
http://dx.doi.org/10.1186/s12964-022-00901-8

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