PROTACs: The Future of Leukemia Therapeutics

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders...

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Autores principales: Anwar, Zubair, Ali, Muhammad Shahzad, Galvano, Antonio, Perez, Alessandro, La Mantia, Maria, Bukhari, Ihtisham, Swiatczak, Bartlomiej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479449/
https://www.ncbi.nlm.nih.gov/pubmed/36120561
http://dx.doi.org/10.3389/fcell.2022.851087
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author Anwar, Zubair
Ali, Muhammad Shahzad
Galvano, Antonio
Perez, Alessandro
La Mantia, Maria
Bukhari, Ihtisham
Swiatczak, Bartlomiej
author_facet Anwar, Zubair
Ali, Muhammad Shahzad
Galvano, Antonio
Perez, Alessandro
La Mantia, Maria
Bukhari, Ihtisham
Swiatczak, Bartlomiej
author_sort Anwar, Zubair
collection PubMed
description The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.
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spelling pubmed-94794492022-09-17 PROTACs: The Future of Leukemia Therapeutics Anwar, Zubair Ali, Muhammad Shahzad Galvano, Antonio Perez, Alessandro La Mantia, Maria Bukhari, Ihtisham Swiatczak, Bartlomiej Front Cell Dev Biol Cell and Developmental Biology The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9479449/ /pubmed/36120561 http://dx.doi.org/10.3389/fcell.2022.851087 Text en Copyright © 2022 Anwar, Ali, Galvano, Perez, La Mantia, Bukhari and Swiatczak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Anwar, Zubair
Ali, Muhammad Shahzad
Galvano, Antonio
Perez, Alessandro
La Mantia, Maria
Bukhari, Ihtisham
Swiatczak, Bartlomiej
PROTACs: The Future of Leukemia Therapeutics
title PROTACs: The Future of Leukemia Therapeutics
title_full PROTACs: The Future of Leukemia Therapeutics
title_fullStr PROTACs: The Future of Leukemia Therapeutics
title_full_unstemmed PROTACs: The Future of Leukemia Therapeutics
title_short PROTACs: The Future of Leukemia Therapeutics
title_sort protacs: the future of leukemia therapeutics
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479449/
https://www.ncbi.nlm.nih.gov/pubmed/36120561
http://dx.doi.org/10.3389/fcell.2022.851087
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