Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two iso...

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Detalles Bibliográficos
Autores principales: Zuckerman, Neta S, Bar-Or, Itay, Sofer, Danit, Bucris, Efrat, Morad, Hagar, Shulman, Lester M, Levi, Nofar, Weiss, Leah, Aguvaev, Irina, Cohen, Zvi, Kestin, Klil, Vasserman, Rinat, Elul, Michal, Fratty, Ilana S, Geva, Miranda, Wax, Marina, Erster, Oran, Yishai, Ruth, Hecht-Sagie, Lior, Alroy-Preis, Sharon, Mendelson, Ella, Weil, Merav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479469/
https://www.ncbi.nlm.nih.gov/pubmed/36111556
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.37.2200694
Descripción
Sumario:We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

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