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Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss

The middle ear transmits sound to the inner ear via vibrations in the eardrum and ossicles, and damage to the middle ear results in conductive hearing loss. Although conductive hearing loss can be corrected by surgery, the currently available clinical investigations cannot always diagnose the ossicu...

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Autores principales: Hirabayashi, Motoki, Kurihara, Sho, Ito, Ryuya, Kurashina, Yuta, Motegi, Masaomi, Okano, Hirotaka James, Yamamoto, Yutaka, Kojima, Hiromi, Asakura, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479494/
https://www.ncbi.nlm.nih.gov/pubmed/36118582
http://dx.doi.org/10.3389/fbioe.2022.967475
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author Hirabayashi, Motoki
Kurihara, Sho
Ito, Ryuya
Kurashina, Yuta
Motegi, Masaomi
Okano, Hirotaka James
Yamamoto, Yutaka
Kojima, Hiromi
Asakura, Takumi
author_facet Hirabayashi, Motoki
Kurihara, Sho
Ito, Ryuya
Kurashina, Yuta
Motegi, Masaomi
Okano, Hirotaka James
Yamamoto, Yutaka
Kojima, Hiromi
Asakura, Takumi
author_sort Hirabayashi, Motoki
collection PubMed
description The middle ear transmits sound to the inner ear via vibrations in the eardrum and ossicles, and damage to the middle ear results in conductive hearing loss. Although conductive hearing loss can be corrected by surgery, the currently available clinical investigations cannot always diagnose the ossicular chain pathology underlying the conductive hearing loss, and even intraoperative findings can be equivocal. Acoustic analysis using finite element models (FEMs) can simulate the sound pressure change at an arbitrary site for each frequency. FEMs are used in acoustic engineering to simulate the frequency-dependent sound pressure distribution at discrete cells in a simulated model and analyze the effects of specific parameters on the audiogram. However, few reports have compared the numerical results obtained using FEMs with data from clinical cases. We used FEMs to simulate audiograms of the air-bone gap (ABG) for various ossicular chain defects and compared these with preoperative audiograms obtained from 44 patients with a normal tympanic membrane who had otosclerosis, middle ear malformations or traumatic ossicular disruption. The simulated audiograms for otosclerosis and attic fixation of the malleus-incus complex both exhibited an up-slope but could be distinguished from each other based on the ABG at 1000 Hz. The simulated audiogram for incudostapedial joint discontinuity exhibited a peak at around 750 Hz and a down-slope above 1000 Hz. In general, the simulated audiograms for otosclerosis, attic fixation and incudostapedial joint discontinuity were consistent with those obtained from clinical cases. Additional simulations indicated that changes in ossicular mass had relatively small effects on ABG. Furthermore, analyses of combination pathologies suggested that the effects of one defect on ABG were added to those of the other defect. These FEM-based findings provide insights into the pathogenesis of conductive hearing loss due to otosclerosis, middle ear malformations and traumatic injury.
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spelling pubmed-94794942022-09-17 Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss Hirabayashi, Motoki Kurihara, Sho Ito, Ryuya Kurashina, Yuta Motegi, Masaomi Okano, Hirotaka James Yamamoto, Yutaka Kojima, Hiromi Asakura, Takumi Front Bioeng Biotechnol Bioengineering and Biotechnology The middle ear transmits sound to the inner ear via vibrations in the eardrum and ossicles, and damage to the middle ear results in conductive hearing loss. Although conductive hearing loss can be corrected by surgery, the currently available clinical investigations cannot always diagnose the ossicular chain pathology underlying the conductive hearing loss, and even intraoperative findings can be equivocal. Acoustic analysis using finite element models (FEMs) can simulate the sound pressure change at an arbitrary site for each frequency. FEMs are used in acoustic engineering to simulate the frequency-dependent sound pressure distribution at discrete cells in a simulated model and analyze the effects of specific parameters on the audiogram. However, few reports have compared the numerical results obtained using FEMs with data from clinical cases. We used FEMs to simulate audiograms of the air-bone gap (ABG) for various ossicular chain defects and compared these with preoperative audiograms obtained from 44 patients with a normal tympanic membrane who had otosclerosis, middle ear malformations or traumatic ossicular disruption. The simulated audiograms for otosclerosis and attic fixation of the malleus-incus complex both exhibited an up-slope but could be distinguished from each other based on the ABG at 1000 Hz. The simulated audiogram for incudostapedial joint discontinuity exhibited a peak at around 750 Hz and a down-slope above 1000 Hz. In general, the simulated audiograms for otosclerosis, attic fixation and incudostapedial joint discontinuity were consistent with those obtained from clinical cases. Additional simulations indicated that changes in ossicular mass had relatively small effects on ABG. Furthermore, analyses of combination pathologies suggested that the effects of one defect on ABG were added to those of the other defect. These FEM-based findings provide insights into the pathogenesis of conductive hearing loss due to otosclerosis, middle ear malformations and traumatic injury. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9479494/ /pubmed/36118582 http://dx.doi.org/10.3389/fbioe.2022.967475 Text en Copyright © 2022 Hirabayashi, Kurihara, Ito, Kurashina, Motegi, Okano, Yamamoto, Kojima and Asakura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Hirabayashi, Motoki
Kurihara, Sho
Ito, Ryuya
Kurashina, Yuta
Motegi, Masaomi
Okano, Hirotaka James
Yamamoto, Yutaka
Kojima, Hiromi
Asakura, Takumi
Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title_full Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title_fullStr Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title_full_unstemmed Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title_short Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
title_sort combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479494/
https://www.ncbi.nlm.nih.gov/pubmed/36118582
http://dx.doi.org/10.3389/fbioe.2022.967475
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