(11)C-methionine- and (18)F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high (18)F-FDG uptake: A case report

BACKGROUND: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and (11)C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on M...

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Detalles Bibliográficos
Autores principales: Tanahashi, Kuniaki, Hirano, Masaki, Chalise, Lushun, Tsugawa, Takahiko, Okumura, Yuka, Hase, Tetsunari, Ohka, Fumiharu, Motomura, Kazuya, Takeuchi, Kazuhito, Nagata, Yuichi, Nakahara, Norimoto, Hashimoto, Naozumi, Saito, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479527/
https://www.ncbi.nlm.nih.gov/pubmed/36128090
http://dx.doi.org/10.25259/SNI_264_2022
Descripción
Sumario:BACKGROUND: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and (11)C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. CASE DESCRIPTION: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. CONCLUSION: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.

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