Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs

A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria in macaques with asymptomatic LTBI. Twelve Indian-origin rhes...

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Detalles Bibliográficos
Autores principales: Sharan, Riti, Ganatra, Shashank R., Singh, Dhiraj K., Cole, Journey, Foreman, Taylor W., Thippeshappa, Rajesh, Peloquin, Charles A., Shivanna, Vinay, Gonzalez, Olga, Day, Cheryl L., Gandhi, Neel R., Dick, Edward J., Hall-Ursone, Shannan, Mehra, Smriti, Schlesinger, Larry S., Rengarajan, Jyothi, Kaushal, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479578/
https://www.ncbi.nlm.nih.gov/pubmed/35862216
http://dx.doi.org/10.1172/JCI161564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479578/
https://www.ncbi.nlm.nih.gov/pubmed/35862216
http://dx.doi.org/10.1172/JCI161564

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