Effects of the peripheral CB(1) receptor antagonist JD5037 in mono— and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hypertension

Pulmonary hypertension (PH) is a disease leading to increased pressure in the pulmonary artery and right heart failure. The adenosine monophosphate-activated protein kinase (AMPK) activator, metformin, has a protective effect against PH. CB(1) receptor blockade reduces the number of pathological alt...

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Detalles Bibliográficos
Autores principales: Remiszewski, Patryk, Pędzińska-Betiuk, Anna, Mińczuk, Krzysztof, Schlicker, Eberhard, Klimek, Justyna, Dzięcioł, Janusz, Malinowska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479636/
https://www.ncbi.nlm.nih.gov/pubmed/36120288
http://dx.doi.org/10.3389/fphar.2022.965613

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