Cargando…

Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study

INTRODUCTION: Large artery intracranial occlusive disease including middle cerebral artery (MCA) is a major contributor to the incidence of stroke in China. The data on the prognosis of symptomatic atherosclerotic MCA occlusions (MCAO) are limited. We aimed to investigate the related factors of unfa...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Bin, Sun, Yufang, Wei, Zheng, Zhang, Yongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479709/
https://www.ncbi.nlm.nih.gov/pubmed/36160353
http://dx.doi.org/10.5114/aoms.2019.87129
_version_ 1784790851411509248
author Chen, Bin
Sun, Yufang
Wei, Zheng
Zhang, Yongbo
author_facet Chen, Bin
Sun, Yufang
Wei, Zheng
Zhang, Yongbo
author_sort Chen, Bin
collection PubMed
description INTRODUCTION: Large artery intracranial occlusive disease including middle cerebral artery (MCA) is a major contributor to the incidence of stroke in China. The data on the prognosis of symptomatic atherosclerotic MCA occlusions (MCAO) are limited. We aimed to investigate the related factors of unfavorable outcomes in patients with stroke associated with MCAO. MATERIAL AND METHODS: A total of 119 patients with MCAO symptom were enrolled in this retrospective longitudinal cohort study. All patients met inclusion criteria of cerebral angiography by CT angiography or magnetic resonance angiography. Stroke severity was assessed on admission using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). RESULTS: We showed an average follow-up time of 46.8 months, within which 20 (19.6%) cases died and 14 (13.7%) cases had stroke recurrence. Using mRS as an evaluation index, the patients were divided into an unfavourable outcome group (mRS > 2, 48 cases) and a favourable outcome group (mRS ≤ 2, 54 cases). Logistic regression analysis suggests that age and NIHSS score were independent risk factors for a poor outcome value. Coexisting other cerebral vascular occlusion was an independent risk factor for stroke recurrence. Age was an independent risk factor for death. CONCLUSIONS: The prognosis of patients with MCAO was generally optimistic, with higher survival rate and longer survival time. As compared, elder age and higher NIHSS score both tend to be associated with worse prognosis of survival. MCAO patients with other extracranial or intracranial vascular occlusion have higher risk of recurrent stroke. Death rate increases with age among the MCAO patients.
format Online
Article
Text
id pubmed-9479709
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-94797092022-09-22 Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study Chen, Bin Sun, Yufang Wei, Zheng Zhang, Yongbo Arch Med Sci Clinical Research INTRODUCTION: Large artery intracranial occlusive disease including middle cerebral artery (MCA) is a major contributor to the incidence of stroke in China. The data on the prognosis of symptomatic atherosclerotic MCA occlusions (MCAO) are limited. We aimed to investigate the related factors of unfavorable outcomes in patients with stroke associated with MCAO. MATERIAL AND METHODS: A total of 119 patients with MCAO symptom were enrolled in this retrospective longitudinal cohort study. All patients met inclusion criteria of cerebral angiography by CT angiography or magnetic resonance angiography. Stroke severity was assessed on admission using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). RESULTS: We showed an average follow-up time of 46.8 months, within which 20 (19.6%) cases died and 14 (13.7%) cases had stroke recurrence. Using mRS as an evaluation index, the patients were divided into an unfavourable outcome group (mRS > 2, 48 cases) and a favourable outcome group (mRS ≤ 2, 54 cases). Logistic regression analysis suggests that age and NIHSS score were independent risk factors for a poor outcome value. Coexisting other cerebral vascular occlusion was an independent risk factor for stroke recurrence. Age was an independent risk factor for death. CONCLUSIONS: The prognosis of patients with MCAO was generally optimistic, with higher survival rate and longer survival time. As compared, elder age and higher NIHSS score both tend to be associated with worse prognosis of survival. MCAO patients with other extracranial or intracranial vascular occlusion have higher risk of recurrent stroke. Death rate increases with age among the MCAO patients. Termedia Publishing House 2019-08-06 /pmc/articles/PMC9479709/ /pubmed/36160353 http://dx.doi.org/10.5114/aoms.2019.87129 Text en Copyright: © 2019 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Chen, Bin
Sun, Yufang
Wei, Zheng
Zhang, Yongbo
Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title_full Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title_fullStr Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title_full_unstemmed Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title_short Long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. Single-centre registration study
title_sort long-term prognosis of patients with stroke associated with middle cerebral artery occlusion. single-centre registration study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479709/
https://www.ncbi.nlm.nih.gov/pubmed/36160353
http://dx.doi.org/10.5114/aoms.2019.87129
work_keys_str_mv AT chenbin longtermprognosisofpatientswithstrokeassociatedwithmiddlecerebralarteryocclusionsinglecentreregistrationstudy
AT sunyufang longtermprognosisofpatientswithstrokeassociatedwithmiddlecerebralarteryocclusionsinglecentreregistrationstudy
AT weizheng longtermprognosisofpatientswithstrokeassociatedwithmiddlecerebralarteryocclusionsinglecentreregistrationstudy
AT zhangyongbo longtermprognosisofpatientswithstrokeassociatedwithmiddlecerebralarteryocclusionsinglecentreregistrationstudy