A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)

INTRODUCTION: In this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways. METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. RESULTS: By luciferase assa...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zhuang, Sui, Rubo, Xia, Dongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479737/
https://www.ncbi.nlm.nih.gov/pubmed/36160329
http://dx.doi.org/10.5114/aoms/151683
_version_ 1784790858378248192
author Zhang, Zhuang
Sui, Rubo
Xia, Dongjian
author_facet Zhang, Zhuang
Sui, Rubo
Xia, Dongjian
author_sort Zhang, Zhuang
collection PubMed
description INTRODUCTION: In this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways. METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. RESULTS: By luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis. CONCLUSIONS: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.
format Online
Article
Text
id pubmed-9479737
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-94797372022-09-22 A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI) Zhang, Zhuang Sui, Rubo Xia, Dongjian Arch Med Sci Research Letter INTRODUCTION: In this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways. METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. RESULTS: By luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis. CONCLUSIONS: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI. Termedia Publishing House 2022-08-30 /pmc/articles/PMC9479737/ /pubmed/36160329 http://dx.doi.org/10.5114/aoms/151683 Text en Copyright: © 2022 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Zhang, Zhuang
Sui, Rubo
Xia, Dongjian
A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title_full A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title_fullStr A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title_full_unstemmed A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title_short A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)
title_sort variant in microrna-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (sci)
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479737/
https://www.ncbi.nlm.nih.gov/pubmed/36160329
http://dx.doi.org/10.5114/aoms/151683
work_keys_str_mv AT zhangzhuang avariantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci
AT suirubo avariantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci
AT xiadongjian avariantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci
AT zhangzhuang variantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci
AT suirubo variantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci
AT xiadongjian variantinmicrorna124isinvolvedinthecontrolofneuralcellapoptosisandassociatedwithrecoveryafterspinalcordinjurysci

Ejemplares similares