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A crescendo of competent coding (c3) contains the Standard Genetic Code

The Standard Genetic Code (SGC) can arise by fusion of partial codes evolved in different individuals, perhaps for differing prior tasks. Such code fragments can be unified into an SGC after later evolution of accurate third-position Crick wobble. Late wobble advent fills in the coding table, leavin...

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Autor principal: Yarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479743/
https://www.ncbi.nlm.nih.gov/pubmed/35868841
http://dx.doi.org/10.1261/rna.079275.122
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author Yarus, Michael
author_facet Yarus, Michael
author_sort Yarus, Michael
collection PubMed
description The Standard Genetic Code (SGC) can arise by fusion of partial codes evolved in different individuals, perhaps for differing prior tasks. Such code fragments can be unified into an SGC after later evolution of accurate third-position Crick wobble. Late wobble advent fills in the coding table, leaving only later development of translational initiation and termination to reach the SGC in separated domains of life. This code fusion mechanism is computationally implemented here. Late Crick wobble after C3 fusion (c3-lCw) is tested for its ability to evolve the SGC. Compared with previously studied isolated coding tables, or with increasing numbers of parallel, but nonfusing codes, c3-lCw reaches the SGC sooner, is successful in a smaller population, and presents accurate and complete codes more frequently. Notably, a long crescendo of SGC-like codes is exposed for selection of superior translation. c3-lCw also effectively suppresses varied disordered assignments, thus converging on a unified code. Such merged codes closely approach the SGC, making its selection plausible. For example: Under routine conditions, ≈1 of 22 c3-lCw environments evolves codes with ≥20 assignments and ≤3 differences from the SGC, notably including codes identical to the Standard Genetic Code.
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spelling pubmed-94797432022-10-01 A crescendo of competent coding (c3) contains the Standard Genetic Code Yarus, Michael RNA Article The Standard Genetic Code (SGC) can arise by fusion of partial codes evolved in different individuals, perhaps for differing prior tasks. Such code fragments can be unified into an SGC after later evolution of accurate third-position Crick wobble. Late wobble advent fills in the coding table, leaving only later development of translational initiation and termination to reach the SGC in separated domains of life. This code fusion mechanism is computationally implemented here. Late Crick wobble after C3 fusion (c3-lCw) is tested for its ability to evolve the SGC. Compared with previously studied isolated coding tables, or with increasing numbers of parallel, but nonfusing codes, c3-lCw reaches the SGC sooner, is successful in a smaller population, and presents accurate and complete codes more frequently. Notably, a long crescendo of SGC-like codes is exposed for selection of superior translation. c3-lCw also effectively suppresses varied disordered assignments, thus converging on a unified code. Such merged codes closely approach the SGC, making its selection plausible. For example: Under routine conditions, ≈1 of 22 c3-lCw environments evolves codes with ≥20 assignments and ≤3 differences from the SGC, notably including codes identical to the Standard Genetic Code. Cold Spring Harbor Laboratory Press 2022-10 /pmc/articles/PMC9479743/ /pubmed/35868841 http://dx.doi.org/10.1261/rna.079275.122 Text en © 2022 Yarus; Published by Cold Spring Harbor Laboratory Press for the RNA Society https://creativecommons.org/licenses/by-nc/4.0/This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Article
Yarus, Michael
A crescendo of competent coding (c3) contains the Standard Genetic Code
title A crescendo of competent coding (c3) contains the Standard Genetic Code
title_full A crescendo of competent coding (c3) contains the Standard Genetic Code
title_fullStr A crescendo of competent coding (c3) contains the Standard Genetic Code
title_full_unstemmed A crescendo of competent coding (c3) contains the Standard Genetic Code
title_short A crescendo of competent coding (c3) contains the Standard Genetic Code
title_sort crescendo of competent coding (c3) contains the standard genetic code
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479743/
https://www.ncbi.nlm.nih.gov/pubmed/35868841
http://dx.doi.org/10.1261/rna.079275.122
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