Uric acidas a predictor of bipolar disorder type 1

INTRODUCTION: It has been shown in the studies that purinergic system dysfunction might have an effect on pathophysiology of bipolar disorder. OBJECTIVES: In this study, our aims were to compare uric acid levels between patient with bipolar disorder type 1 (BPD1) and healthy controls (HC) and to evaluate the validity of uric acid in predicting bipolar disorder. METHODS: Consecutive outpatients with a diagnosis of euthymic BPD-1 (n=75) and HC (n=75) were included in the study. The subjects were evaluated with Sociodemographic Data Form, Young Mani Rating Scale (YMRS), Beck Depression Scale. Serum uric acid was measured using an auto analyzer. RESULTS: Serum uric acid level in BPD1 group was significantly higher than HC. Significant efficacy of uric acid value was observed in the differentiation of BPD1 and HC [Area under the curve 0.708(0.626-0.790)]. Significant efficacy of uric acid 5.4 cut off value was observed in the differentiation of BPD1 and HC [Area under the curve 0.667 (0.579-0.8754)]. Sensitivity was 50.7%, positive predictive value (PPV) was 74.5%, specificity was 82.7%, negative predictive value (NPV) was 62.6%. CONCLUSIONS: Serum uric acid value is effective in detecting bipolar patients. DISCLOSURE: No significant relationships.